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Epoprostenol Side Effects

The most commonly reported side effects of epoprostenol include dyspnoea, headache, and diarrhoea, based on 20,654 FDA adverse event reports from 2004 to 2025.

Epoprostenol side effects

Percentages show how often each reaction appears relative to total reports for epoprostenol.

1
Dyspnoea17.3%3,580
2
Headache14.1%2,911
3
Diarrhoea13.3%2,748
4
Nausea11.9%2,449
5
Pain In Jaw10.8%2,225
6
Death9.0%1,861
7
Flushing7.2%1,480
8
Fatigue6.8%1,413
9
Pulmonary Arterial Hypertension6.7%1,382
10
Vomiting6.4%1,330
11
Pneumonia6.0%1,238
12
Fluid Retention5.9%1,221
13
Malaise5.8%1,204
14
Hospitalisation5.8%1,196
15
Dizziness5.4%1,115

These are voluntary reports and do not establish that epoprostenol caused these reactions.

Report severity

84.0%Serious17,358 reports
63.6%Hospitalizations13,143 reports
20.7%Fatal4,278 reports

Seriousness is determined by the reporter, not by OpenClaim.

Epoprostenol drug interactions

Other drugs that appear in adverse event reports alongside epoprostenol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ambrisentan17.4%3,589
2
Macitentan12.5%2,572
3
Bosentan8.4%1,743
4
Treprostinil6.7%1,390
5
Sildenafil-citrate5.0%1,023
6
Tadalafil3.8%784
7
Selexipag3.3%677
8
Riociguat3.0%616
9
Furosemide1.1%223
10
Warfarin0.9%180
11
Heparin0.9%180
12
Iloprost0.8%168
13
Sotatercept-csrk0.6%115
14
Nitric-oxide0.5%111
15
Remdesivir0.5%106

Taken alongside

1
Sildenafil-citrate24.7%5,099
2
Warfarin20.2%4,176
3
Tadalafil18.4%3,809
4
Furosemide10.7%2,219
5
Ambrisentan10.1%2,079
6
Spironolactone7.0%1,451
7
Macitentan6.5%1,347
8
Oxygen5.2%1,077
9
Riociguat4.8%986
10
Bosentan4.1%841
11
Treprostinil3.8%793
12
Potassium-chloride3.5%733
13
Acetaminophen3.4%693
14
Apixaban3.1%647
15
Digoxin3.1%642

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports epoprostenol side effects

71.3% of epoprostenol adverse event reports involve female patients and 21.0% involve male patients. The largest age group is adult at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female71.3%
Male21.0%
Unknown7.7%

Age group

< 21.8%
2–111.3%
12–171.8%
18–6474.0%
65+21.1%

What is epoprostenol used for

Conditions and purposes for which patients were taking epoprostenol when the adverse event was reported.

Acute Respiratory Distress SyndromeAcute Respiratory FailureAlveolar Capillary DysplasiaAnticoagulant TherapyAnticoagulation Drug LevelAortic Valve DiseaseArrhythmiaArterial DisorderAtrial Septal DefectAcute Kidney InjuryAcute On Chronic Liver FailureAcute Respiratory Distress SyndromeAdverse Drug ReactionAngiopathyAnticoagulant Therapy

Showing 15 of 232 indications

Epoprostenol brand names and reporting trend

Epoprostenol is sold under the brand name Veletri.

Brand names

Veletri6,511

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking epoprostenol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.