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Eplontersen Side Effects

The most commonly reported side effects of eplontersen include death, neuropathy peripheral, and fatigue, based on 323 FDA adverse event reports from 2010 to 2025.

Eplontersen side effects

Percentages show how often each reaction appears relative to total reports for eplontersen.

1
Death10.8%35
2
Neuropathy Peripheral10.5%34
3
Fatigue7.1%23
4
Nausea5.3%17
5
Dyspnoea4.6%15
6
Pain4.3%14
7
Pain In Extremity4.0%13
8
Diarrhoea3.7%12
9
Pneumonia3.4%11
10
Malaise3.1%10
11
Thrombosis3.1%10
12
Constipation2.8%9
13
Vision Blurred2.5%8
14
Product Dose Omission Issue2.5%8
15
Atrial Fibrillation2.5%8

These are voluntary reports and do not establish that eplontersen caused these reactions.

Report severity

71.8%Serious232 reports
24.1%Hospitalizations78 reports
11.8%Fatal38 reports

Seriousness is determined by the reporter, not by OpenClaim.

Eplontersen drug interactions

Other drugs that appear in adverse event reports alongside eplontersen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tafamidis1.2%4
2
Dapagliflozin0.6%2
3
Lanreotide-acetate0.3%1
4
Inotersen-sodium0.3%1
5
Acoramidis-hydrochloride0.3%1
6
Apixaban0.3%1
7
Vutrisiran-sodium0.3%1
8
Spironolactone0.3%1

Taken alongside

1
Furosemide1.9%6
2
Tafamidis1.9%6
3
Vitamin-a1.2%4
4
Magnesium-acetate-tetrahydrate0.9%3
5
Spironolactone0.9%3
6
Simvastatin0.6%2
7
Tamsulosin-hydrochloride0.6%2
8
Duloxetine-hydrochloride0.6%2
9
Empagliflozin0.6%2
10
Metoprolol0.6%2
11
Apixaban0.6%2
12
Diphenhydramine0.6%2
13
Torsemide0.6%2
14
Lisinopril0.6%2
15
Atorvastatin-calcium0.6%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports eplontersen side effects

44.9% of eplontersen adverse event reports involve female patients and 46.4% involve male patients. The largest age group is elderly at 83%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.9%
Male46.4%
Unknown8.7%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6417.4%
65+82.6%

What is eplontersen used for

Conditions and purposes for which patients were taking eplontersen when the adverse event was reported.

Acquired Attr AmyloidosisAmyloidosisCardiac AmyloidosisFamilial AmyloidosisHereditary Attr Amyloid CardiomyopathyHereditary DisorderHereditary Neuropathic AmyloidosisNeuropathic ArthropathyNeuropathy PeripheralPolyneuropathyProduct Used For Unknown Indication

Eplontersen brand names and reporting trend

Eplontersen is sold under the brand name Wainua (autoinjector).

Brand names

Wainua (autoinjector)171

Quarterly reports (20102025)

201020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking eplontersen with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.