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Epirubicin Side Effects

The most commonly reported side effects of epirubicin include nausea, neutropenia, and vomiting, based on 23,904 FDA adverse event reports from 2004 to 2025. 2.1% of reports found the drug to be ineffective.

Epirubicin side effects

Percentages show how often each reaction appears relative to total reports for epirubicin.

1
Nausea6.1%1,447
2
Neutropenia4.9%1,172
3
Vomiting4.7%1,112
4
Alopecia4.6%1,098
5
Febrile Neutropenia4.5%1,078
6
Diarrhoea4.4%1,062
7
Myelosuppression4.3%1,024
8
Pyrexia4.1%969
9
Fatigue3.7%882
10
Asthenia3.7%875
11
Death3.5%846
12
White Blood Cell Count Decreased3.5%844
13
Off Label Use3.3%787
14
Disease Progression3.1%733
15
Anaemia2.8%674

These are voluntary reports and do not establish that epirubicin caused these reactions.

Report severity

98.2%Serious23,483 reports
37.5%Hospitalizations8,975 reports
13.9%Fatal3,321 reports

Seriousness is determined by the reporter, not by OpenClaim.

Epirubicin drug interactions

Other drugs that appear in adverse event reports alongside epirubicin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cyclophosphamide48.7%11,649
2
Fluorouracil22.8%5,446
3
Docetaxel19.8%4,739
4
Paclitaxel16.9%4,047
5
Trastuzumab13.7%3,277
6
Capecitabine11.1%2,662
7
Cisplatin8.2%1,953
8
Carboplatin7.6%1,821
9
Vincristine-sulfate5.9%1,420
10
Pembrolizumab5.5%1,314
11
Pertuzumab4.8%1,153
12
Rituximab4.7%1,114
13
Pegfilgrastim4.7%1,112
14
Doxorubicin-hydrochloride4.5%1,074
15
Sodium-chloride4.4%1,047

Taken alongside

1
Cyclophosphamide14.2%3,396
2
Dexamethasone8.1%1,936
3
Fluorouracil6.2%1,477
4
Ondansetron4.1%971
5
Paclitaxel3.5%848
6
Docetaxel3.4%812
7
Sodium-chloride3.0%714
8
Aprepitant2.7%637
9
Acetaminophen2.6%632
10
Pegfilgrastim2.3%553
11
Omeprazole2.3%540
12
Metoclopramide-hydrochloride2.0%472
13
Levothyroxine-sodium1.7%416
14
Prednisone1.7%401
15
Palonosetron-hydrochloride1.6%384

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports epirubicin side effects

73.0% of epirubicin adverse event reports involve female patients and 13.7% involve male patients. The largest age group is adult at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female73.0%
Male13.7%
Unknown13.3%

Age group

< 20.9%
2–111.2%
12–170.6%
18–6474.4%
65+23.0%

What is epirubicin used for

Conditions and purposes for which patients were taking epirubicin when the adverse event was reported.

Acute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma Of AppendixAdenocarcinoma Of The CervixAdenocarcinoma PancreasAdjuvant TherapyAdrenocortical CarcinomaAlveolar RhabdomyosarcomaAlveolar Soft Part SarcomaAmyloidosisAnaplastic Large Cell Lymphoma T- And Null-cell Types

Showing 15 of 735 indications

Epirubicin brand names and reporting trend

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking epirubicin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.