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Epcoritamab Side Effects

The most commonly reported side effects of epcoritamab include cytokine release syndrome, pyrexia, and diffuse large b-cell lymphoma, based on 3,271 FDA adverse event reports from 2021 to 2025.

Epcoritamab side effects

Percentages show how often each reaction appears relative to total reports for epcoritamab.

1
Cytokine Release Syndrome30.0%980
2
Pyrexia10.6%346
3
Diffuse Large B-cell Lymphoma9.8%322
4
Off Label Use7.9%259
5
Febrile Neutropenia7.3%240
6
Diffuse Large B-cell Lymphoma Refractory6.4%210
7
Pneumonia6.1%199
8
Covid-195.4%177
9
Immune Effector Cell-associated Neurotoxicity Syndrome5.3%173
10
Sepsis4.2%137
11
Neutropenia3.4%110
12
Hypotension3.3%108
13
Death3.1%100
14
Diarrhoea3.0%97
15
Disease Progression2.9%96

These are voluntary reports and do not establish that epcoritamab caused these reactions.

Report severity

97.2%Serious3,180 reports
59.6%Hospitalizations1,950 reports
26.2%Fatal857 reports

Seriousness is determined by the reporter, not by OpenClaim.

Epcoritamab drug interactions

Other drugs that appear in adverse event reports alongside epcoritamab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab43.0%1,407
2
Cyclophosphamide25.4%830
3
Doxorubicin-hydrochloride25.2%825
4
Prednisone23.8%780
5
Vincristine-sulfate23.7%776
6
Lenalidomide12.8%418
7
Oxaliplatin9.9%324
8
Gemcitabine9.1%299
9
Carboplatin5.6%184
10
Dexamethasone5.4%176
11
Cytarabine4.1%133
12
Bendamustine-hydrochloride3.3%108
13
Etoposide2.9%96
14
Prednisolone2.7%88
15
Ifosfamide2.6%84

Taken alongside

1
Acetaminophen34.9%1,140
2
Acyclovir32.2%1,052
3
Allopurinol21.2%694
4
Dexamethasone18.8%616
5
Ondansetron16.0%524
6
Pantoprazole-sodium15.3%500
7
Omeprazole13.7%447
8
Sulfamethoxazole12.6%412
9
Filgrastim12.5%408
10
Prednisolone12.0%391
11
Trimethoprim11.8%385
12
Methylprednisolone11.1%362
13
Prednisone10.5%343
14
Furosemide10.1%331
15
Potassium-chloride9.7%318

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports epcoritamab side effects

35.7% of epcoritamab adverse event reports involve female patients and 49.9% involve male patients. The largest age group is elderly at 69%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.7%
Male49.9%
Unknown14.4%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6431.0%
65+68.9%

What is epcoritamab used for

Conditions and purposes for which patients were taking epcoritamab when the adverse event was reported.

B-cell Lymphoma Stage IvB-cell LymphomaB-cell Lymphoma RefractoryB-cell Small Lymphocytic LymphomaBurkitt^s LymphomaBurkitt^s Lymphoma RefractoryBurkitt^s Lymphoma Stage IiiCovid-19Central Nervous System LymphomaChronic Lymphocytic LeukaemiaChronic Lymphocytic Leukaemia RefractoryChronic Lymphocytic Leukaemia TransformationCytokine Release SyndromeDiffuse Large B-cell LymphomaDiffuse Large B-cell Lymphoma Stage Iv

Showing 15 of 58 indications

Epcoritamab brand names and reporting trend

Epcoritamab is sold under the brand name Epkinly.

Brand names

Epkinly6,859

Quarterly reports (20212025)

2021202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking epcoritamab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.