OpenClaim

Enzalutamide Side Effects

The most commonly reported side effects of enzalutamide include fatigue, death, and malignant neoplasm progression, based on 57,858 FDA adverse event reports from 2012 to 2025. 7.0% of reports found the drug to be ineffective.

Enzalutamide side effects

Percentages show how often each reaction appears relative to total reports for enzalutamide.

1
Fatigue17.6%10,183
2
Death13.3%7,691
3
Malignant Neoplasm Progression9.4%5,414
4
Prostatic Specific Antigen Increased7.4%4,304
5
Asthenia7.1%4,127
6
Drug Ineffective7.0%4,051
7
Hot Flush6.6%3,821
8
Decreased Appetite5.9%3,390
9
Nausea5.6%3,252
10
Dizziness5.4%3,119
11
Diarrhoea4.8%2,797
12
Back Pain4.0%2,287
13
Arthralgia3.7%2,129
14
Underdose3.6%2,067
15
Constipation3.1%1,808

These are voluntary reports and do not establish that enzalutamide caused these reactions.

Report severity

61.5%Serious35,592 reports
18.9%Hospitalizations10,938 reports
19.6%Fatal11,356 reports

Seriousness is determined by the reporter, not by OpenClaim.

Enzalutamide drug interactions

Other drugs that appear in adverse event reports alongside enzalutamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Leuprolide5.8%3,340
2
Relugolix2.9%1,689
3
Abiraterone-acetate2.7%1,540
4
Denosumab1.5%892
5
Docetaxel1.5%886
6
Prednisone1.5%858
7
Bicalutamide1.0%553
8
Cabazitaxel0.7%379
9
Talazoparib-tosylate0.6%373
10
Radium-ra-223-dichloride0.6%342
11
Zoledronic-acid0.6%337
12
Degarelix-acetate0.5%272
13
Tamsulosin-hydrochloride0.4%238
14
Goserelin0.4%234
15
Metformin0.3%193

Taken alongside

1
Leuprolide6.4%3,684
2
Aspirin6.3%3,650
3
Tamsulosin-hydrochloride4.8%2,787
4
Ergocalciferol4.8%2,786
5
Prednisone4.8%2,770
6
Atorvastatin-calcium4.7%2,702
7
Acetaminophen4.6%2,687
8
Amlodipine4.3%2,470
9
Metoprolol3.9%2,253
10
Calcium3.8%2,186
11
Lisinopril3.7%2,131
12
Denosumab3.3%1,936
13
Metformin3.3%1,933
14
Furosemide3.3%1,911
15
Bicalutamide3.2%1,878

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports enzalutamide side effects

0.6% of enzalutamide adverse event reports involve female patients and 95.3% involve male patients. The largest age group is elderly at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female0.6%
Male95.3%
Unknown4.0%

Age group

< 2<0.1%
2–11<0.1%
12–170.0%
18–6413.8%
65+86.2%

What is enzalutamide used for

Conditions and purposes for which patients were taking enzalutamide when the adverse event was reported.

Acute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma MetastaticAgranulocytosisAnaemiaAndrogen Replacement TherapyAndrogens IncreasedAnkle FractureAntiandrogen TherapyAnticoagulant TherapyArthropathyAutonomic NeuropathyAdenocarcinomaAdenocarcinoma Metastatic

Showing 15 of 366 indications

Enzalutamide brand names and reporting trend

Enzalutamide is sold under the brand name Enzalutamide.

Brand names

Enzalutamide16,464

Quarterly reports (20122025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking enzalutamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.