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Enfuvirtide Side Effects

The most commonly reported side effects of enfuvirtide include depression, drug interaction, and psychotic disorder, based on 3,565 FDA adverse event reports from 2004 to 2025.

Enfuvirtide side effects

Percentages show how often each reaction appears relative to total reports for enfuvirtide.

1
Depression14.4%513
2
Drug Interaction14.2%506
3
Psychotic Disorder8.3%295
4
Loss Of Personal Independence In Daily Activities6.3%223
5
Anxiety5.8%206
6
Vomiting5.8%206
7
Nausea5.6%198
8
Pneumonia5.5%196
9
Schizophrenia5.2%186
10
Cholelithiasis5.2%186
11
Lipodystrophy Acquired4.8%171
12
Psychiatric Decompensation4.5%160
13
Hepatic Enzyme Increased4.4%157
14
Mitochondrial Toxicity4.2%148
15
Hepatotoxicity4.1%147

These are voluntary reports and do not establish that enfuvirtide caused these reactions.

Report severity

91.5%Serious3,263 reports
41.0%Hospitalizations1,463 reports
13.6%Fatal485 reports

Seriousness is determined by the reporter, not by OpenClaim.

Enfuvirtide drug interactions

Other drugs that appear in adverse event reports alongside enfuvirtide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ritonavir36.8%1,312
2
Lamivudine23.4%835
3
Tenofovir21.5%765
4
Raltegravir-potassium21.0%748
5
Lopinavir20.3%722
6
Efavirenz17.9%638
7
Atazanavir-sulfate15.0%536
8
Quetiapine-fumarate13.8%491
9
Clonazepam13.4%479
10
Zidovudine12.9%459
11
Tipranavir12.8%456
12
Darunavir12.1%430
13
Didanosine9.9%352
14
Bupropion9.3%330
15
Emtricitabine8.7%311

Taken alongside

1
Ritonavir24.3%865
2
Tenofovir22.5%803
3
Lamivudine19.5%695
4
Emtricitabine14.8%529
5
Lopinavir13.9%497
6
Abacavir12.0%427
7
Sulfamethoxazole10.1%360
8
Trimethoprim9.7%345
9
Zidovudine7.2%258
10
Raltegravir-potassium6.9%247
11
Darunavir6.6%237
12
Loperamide-hydrochloride6.5%231
13
Tipranavir6.0%215
14
Didanosine5.9%211
15
Fluconazole5.5%197

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports enfuvirtide side effects

21.4% of enfuvirtide adverse event reports involve female patients and 67.8% involve male patients. The largest age group is adult at 95%. These figures reflect who reports side effects, not underlying risk.

Sex

Female21.4%
Male67.8%
Unknown10.8%

Age group

< 22.6%
2–110.5%
12–170.6%
18–6494.6%
65+1.7%

What is enfuvirtide used for

Conditions and purposes for which patients were taking enfuvirtide when the adverse event was reported.

Acquired Immunodeficiency SyndromeAntiretroviral TherapyAntiviral Drug LevelAntiviral ProphylaxisAntiviral TreatmentAutoimmune DisorderAntiretroviral TherapyAntiviral TreatmentBlood Hiv RnaBurkitt's LymphomaCongenital Hiv InfectionDrug EruptionDrug Exposure During PregnancyDrug Use For Unknown IndicationDepression

Showing 15 of 51 indications

Enfuvirtide brand names and reporting trend

Enfuvirtide is sold under the brand name Fuzeon.

Brand names

Fuzeon2,506

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking enfuvirtide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.