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Enfortumab Side Effects

The most commonly reported side effects of enfortumab include rash, neuropathy peripheral, and malignant neoplasm progression, based on 6,970 FDA adverse event reports from 2004 to 2025.

Enfortumab side effects

Percentages show how often each reaction appears relative to total reports for enfortumab.

1
Rash12.2%847
2
Neuropathy Peripheral10.4%726
3
Malignant Neoplasm Progression10.2%711
4
Diarrhoea6.0%415
5
Fatigue5.7%399
6
Pruritus5.6%393
7
Decreased Appetite5.5%381
8
Death5.1%357
9
Off Label Use4.7%326
10
Alopecia4.2%292
11
Nausea3.9%272
12
Pyrexia3.8%267
13
Skin Disorder3.3%232
14
Taste Disorder3.3%230
15
Hyperglycaemia3.2%226

These are voluntary reports and do not establish that enfortumab caused these reactions.

Report severity

87.9%Serious6,125 reports
37.3%Hospitalizations2,601 reports
20.4%Fatal1,420 reports

Seriousness is determined by the reporter, not by OpenClaim.

Enfortumab drug interactions

Other drugs that appear in adverse event reports alongside enfortumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pembrolizumab27.9%1,948
2
Vancomycin2.2%151
3
Gemcitabine1.6%114
4
Cisplatin1.6%110
5
Sulfamethoxazole0.8%59
6
Trimethoprim0.8%59
7
Methotrexate0.8%56
8
Ciprofloxacin0.8%54
9
Metronidazole0.8%53
10
Carboplatin0.8%53
11
Amphotericin-b0.7%52
12
Avelumab0.7%49
13
Methylprednisolone0.7%48
14
Durvalumab0.7%46
15
Mycophenolate0.6%43

Taken alongside

1
Pembrolizumab12.5%874
2
Acetaminophen3.4%234
3
Amlodipine2.5%171
4
Vancomycin2.3%163
5
Gemcitabine2.3%161
6
Prednisone2.1%146
7
Levothyroxine-sodium2.1%143
8
Atorvastatin-calcium2.0%140
9
Omeprazole1.8%128
10
Aspirin1.8%122
11
Cisplatin1.8%122
12
Metformin1.7%118
13
Rosuvastatin1.7%116
14
Insulin1.6%115
15
Dexamethasone1.6%112

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports enfortumab side effects

24.9% of enfortumab adverse event reports involve female patients and 70.6% involve male patients. The largest age group is elderly at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female24.9%
Male70.6%
Unknown4.6%

Age group

< 20.4%
2–111.0%
12–170.8%
18–6424.6%
65+73.2%

What is enfortumab used for

Conditions and purposes for which patients were taking enfortumab when the adverse event was reported.

Abdominal InfectionAbscessAcute Lymphocytic LeukaemiaAdverse EventAmputationAntibiotic ProphylaxisAntibiotic TherapyAntiinflammatory TherapyAplasiaArthritis BacterialAscitesAdenocarcinoma Of ColonAdrenal Gland CancerBacteraemiaBacterial Culture Positive

Showing 15 of 247 indications

Enfortumab brand names and reporting trend

Enfortumab is sold under the brand name Padcev.

Brand names

Padcev4,600

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking enfortumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.