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Encorafenib Side Effects

The most commonly reported side effects of encorafenib include death, off label use, and nausea, based on 9,252 FDA adverse event reports from 2013 to 2025.

Encorafenib side effects

Percentages show how often each reaction appears relative to total reports for encorafenib.

1
Death11.7%1,084
2
Off Label Use11.7%1,084
3
Nausea8.7%804
4
Fatigue7.8%726
5
Diarrhoea6.5%604
6
Pyrexia6.2%573
7
Neoplasm Progression6.0%551
8
Product Use In Unapproved Indication5.6%519
9
Vomiting4.8%446
10
Rash4.8%440
11
Serous Retinal Detachment3.5%325
12
Arthralgia3.2%296
13
Malaise3.0%280
14
Decreased Appetite3.0%280
15
Asthenia2.5%230

These are voluntary reports and do not establish that encorafenib caused these reactions.

Report severity

69.0%Serious6,382 reports
27.5%Hospitalizations2,547 reports
16.5%Fatal1,527 reports

Seriousness is determined by the reporter, not by OpenClaim.

Encorafenib drug interactions

Other drugs that appear in adverse event reports alongside encorafenib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Binimetinib69.5%6,431
2
Cetuximab10.9%1,008
3
Nivolumab4.8%446
4
Ipilimumab3.3%306
5
Fluorouracil1.9%175
6
Oxaliplatin1.7%160
7
Trametinib1.4%131
8
Dabrafenib-mesylate1.4%128
9
Pembrolizumab1.2%108
10
Levoleucovorin1.1%103
11
Irinotecan-hydrochloride0.9%81
12
Bevacizumab0.8%75
13
Vemurafenib0.8%73
14
Panitumumab0.7%69
15
Cobimetinib-fumarate0.6%57

Taken alongside

1
Cetuximab7.0%649
2
Acetaminophen5.2%483
3
Ondansetron5.2%482
4
Levothyroxine-sodium4.8%442
5
Pantoprazole-sodium3.9%362
6
Amlodipine3.8%349
7
Omeprazole3.5%321
8
Dexamethasone3.5%320
9
Oxycodone3.0%281
10
Ergocalciferol3.0%275
11
Atorvastatin-calcium2.9%271
12
Prochlorperazine2.8%257
13
Aspirin2.7%252
14
Metformin2.6%240
15
Binimetinib2.6%240

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports encorafenib side effects

36.3% of encorafenib adverse event reports involve female patients and 37.1% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.3%
Male37.1%
Unknown26.5%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6445.7%
65+54.2%

What is encorafenib used for

Conditions and purposes for which patients were taking encorafenib when the adverse event was reported.

Addison^s DiseaseAdenocarcinoma Of ColonAdverse ReactionAmeloblastic CarcinomaAnaemiaAnaemia Vitamin B12 DeficiencyAnal CancerAnaplastic Thyroid CancerAppendix CancerAstrocytomaAstrocytoma MalignantAsymptomatic Hiv InfectionAutoimmune HepatitisAcral Lentiginous MelanomaAdenocarcinoma

Showing 15 of 320 indications

Encorafenib brand names and reporting trend

Encorafenib is sold under the brand name Braftovi.

Brand names

Braftovi2,511

Quarterly reports (20132025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking encorafenib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.