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Enalapril Side Effects

The most commonly reported side effects of enalapril include diarrhoea, acute kidney injury, and fatigue, based on 64,043 FDA adverse event reports from 2004 to 2025. 3.5% of reports found the drug to be ineffective.

Enalapril side effects

Percentages show how often each reaction appears relative to total reports for enalapril.

1
Diarrhoea3.7%2,377
2
Acute Kidney Injury3.6%2,287
3
Drug Ineffective3.5%2,237
4
Fatigue3.2%2,079
5
Dyspnoea3.2%2,057
6
Nausea3.1%1,997
7
Drug Interaction3.0%1,947
8
Off Label Use2.8%1,776
9
Dizziness2.7%1,752
10
Headache2.5%1,580
11
Vomiting2.4%1,522
12
Pain2.3%1,477
13
Malaise2.3%1,468
14
Hypertension2.2%1,390
15
Asthenia2.1%1,365

These are voluntary reports and do not establish that enalapril caused these reactions.

Report severity

83.6%Serious53,550 reports
48.3%Hospitalizations30,950 reports
10.6%Fatal6,816 reports

Seriousness is determined by the reporter, not by OpenClaim.

Enalapril drug interactions

Other drugs that appear in adverse event reports alongside enalapril. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metformin3.3%2,134
2
Adalimumab3.2%2,074
3
Furosemide2.6%1,688
4
Amlodipine2.5%1,572
5
Omeprazole2.2%1,403
6
Hydrochlorothiazide2.2%1,399
7
Aspirin2.2%1,379
8
Atorvastatin-calcium2.0%1,287
9
Lenalidomide1.9%1,225
10
Rosiglitazone-maleate1.8%1,139
11
Insulin1.7%1,083
12
Simvastatin1.6%1,000
13
Metoprolol1.5%988
14
Etanercept1.5%978
15
Esomeprazole1.5%975

Taken alongside

1
Aspirin18.7%11,971
2
Furosemide14.7%9,390
3
Metformin12.4%7,916
4
Atorvastatin-calcium11.4%7,280
5
Amlodipine11.3%7,251
6
Simvastatin11.2%7,165
7
Omeprazole10.9%6,984
8
Metoprolol10.8%6,910
9
Acetaminophen10.4%6,636
10
Hydrochlorothiazide10.1%6,456
11
Levothyroxine-sodium8.5%5,437
12
Enalaprilat8.2%5,281
13
Insulin7.7%4,922
14
Carvedilol6.2%3,949
15
Prednisone6.1%3,897

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports enalapril side effects

48.0% of enalapril adverse event reports involve female patients and 46.8% involve male patients. The largest age group is elderly at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.0%
Male46.8%
Unknown5.1%

Age group

< 21.0%
2–112.0%
12–171.6%
18–6439.7%
65+55.8%

What is enalapril used for

Conditions and purposes for which patients were taking enalapril when the adverse event was reported.

Accelerated HypertensionAccidental ExposureAcute Coronary SyndromeAcute Myocardial InfarctionAcute Pulmonary OedemaAlbumin UrineAllogenic Stem Cell TransplantationAlport's SyndromeAlport^s SyndromeAmputationAnaphylactic ReactionAneurysm RupturedAngina PectorisAngina UnstableAngioedema

Showing 15 of 663 indications

Enalapril brand names and reporting trend

Enalapril is sold under the brand name Teczem.

Brand names

Teczem45

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking enalapril with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.