OpenClaim

Emtricitabine Side Effects

The most commonly reported side effects of emtricitabine include bone density decreased, chronic kidney disease, and renal failure, based on 86,589 FDA adverse event reports from 2004 to 2025.

Emtricitabine side effects

Percentages show how often each reaction appears relative to total reports for emtricitabine.

1
Bone Density Decreased25.1%21,706
2
Chronic Kidney Disease15.6%13,512
3
Renal Failure13.2%11,404
4
Bone Loss13.1%11,324
5
Osteonecrosis13.0%11,233
6
Tooth Loss12.4%10,695
7
Multiple Fractures11.8%10,203
8
Pain11.0%9,568
9
Osteoporosis11.0%9,524
10
Renal Injury10.9%9,447
11
Emotional Distress10.4%8,994
12
Anxiety10.1%8,744
13
Skeletal Injury9.7%8,357
14
Anhedonia9.1%7,894
15
Osteopenia6.3%5,498

These are voluntary reports and do not establish that emtricitabine caused these reactions.

Report severity

77.0%Serious66,662 reports
17.3%Hospitalizations14,980 reports
4.9%Fatal4,268 reports

Seriousness is determined by the reporter, not by OpenClaim.

Emtricitabine drug interactions

Other drugs that appear in adverse event reports alongside emtricitabine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tenofovir81.7%70,763
2
Efavirenz23.9%20,715
3
Cobicistat14.8%12,843
4
Elvitegravir13.3%11,523
5
Ritonavir10.1%8,749
6
Rilpivirine10.1%8,715
7
Bictegravir7.5%6,466
8
Darunavir5.8%5,003
9
Raltegravir-potassium4.8%4,153
10
Dolutegravir4.7%4,056
11
Atazanavir-sulfate4.1%3,564
12
Lamivudine3.9%3,411
13
Lopinavir3.2%2,742
14
Zidovudine2.5%2,192
15
Nevirapine1.9%1,650

Taken alongside

1
Tenofovir37.8%32,773
2
Bictegravir12.8%11,083
3
Cobicistat10.5%9,102
4
Elvitegravir8.3%7,182
5
Ritonavir6.5%5,609
6
Darunavir5.1%4,410
7
Dolutegravir4.0%3,483
8
Rilpivirine3.9%3,353
9
Raltegravir-potassium3.4%2,984
10
Lamivudine3.3%2,863
11
Efavirenz3.1%2,657
12
Acetaminophen2.8%2,394
13
Sulfamethoxazole2.7%2,356
14
Atazanavir-sulfate2.4%2,092
15
Trimethoprim2.4%2,046

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports emtricitabine side effects

25.9% of emtricitabine adverse event reports involve female patients and 64.0% involve male patients. The largest age group is adult at 91%. These figures reflect who reports side effects, not underlying risk.

Sex

Female25.9%
Male64.0%
Unknown10.2%

Age group

< 22.3%
2–110.2%
12–170.3%
18–6490.8%
65+6.4%

What is emtricitabine used for

Conditions and purposes for which patients were taking emtricitabine when the adverse event was reported.

Abdominal PainAbnormal BehaviourAccident At WorkAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAcquired Immunodeficiency SyndromeAcute Hepatitis CAcute Hiv InfectionAcute Kidney InjuryAdverse ReactionAidsAids Dementia ComplexAids RetinopathyAnal Cancer

Showing 15 of 397 indications

Emtricitabine brand names and reporting trend

Emtricitabine is sold under the brand name Truvada.

Brand names

Truvada8,312

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking emtricitabine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.