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Eltrombopag Side Effects

The most commonly reported side effects of eltrombopag include platelet count decreased, death, and platelet count increased, based on 23,295 FDA adverse event reports from 2004 to 2025. 7.1% of reports found the drug to be ineffective.

Eltrombopag side effects

Percentages show how often each reaction appears relative to total reports for eltrombopag.

1
Platelet Count Decreased16.5%3,836
2
Death13.2%3,079
3
Drug Ineffective7.1%1,652
4
Platelet Count Increased4.5%1,056
5
Fatigue4.5%1,052
6
Headache4.0%923
7
Off Label Use3.6%850
8
Diarrhoea3.4%792
9
Nausea3.3%771
10
Product Use In Unapproved Indication3.2%736
11
Malaise2.5%574
12
Pyrexia2.3%527
13
Thrombocytopenia2.2%502
14
Pneumonia2.1%494
15
Contusion2.1%494

These are voluntary reports and do not establish that eltrombopag caused these reactions.

Report severity

66.0%Serious15,366 reports
25.3%Hospitalizations5,894 reports
21.5%Fatal5,012 reports

Seriousness is determined by the reporter, not by OpenClaim.

Eltrombopag drug interactions

Other drugs that appear in adverse event reports alongside eltrombopag. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cyclosporine4.4%1,017
2
Rituximab3.3%780
3
Romiplostim2.4%557
4
Prednisone2.0%464
5
Dexamethasone1.8%426
6
Mycophenolate1.7%386
7
Ribavirin1.5%341
8
Fostamatinib-disodium1.4%331
9
Prednisolone1.2%281
10
Cyclophosphamide1.1%246
11
Peginterferon1.0%236
12
Azacitidine0.9%202
13
Methylprednisolone0.8%197
14
Fludarabine-phosphate0.7%164
15
Tacrolimus0.6%143

Taken alongside

1
Prednisone4.4%1,026
2
Furosemide2.9%666
3
Acetaminophen2.8%647
4
Amlodipine2.6%598
5
Levothyroxine-sodium2.3%545
6
Omeprazole2.3%544
7
Acyclovir2.2%520
8
Cyclosporine2.2%502
9
Prednisolone2.0%461
10
Pantoprazole-sodium1.9%454
11
Ergocalciferol1.9%453
12
Folic-acid1.7%403
13
Metoprolol1.7%402
14
Dexamethasone1.6%378
15
Aspirin1.6%373

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports eltrombopag side effects

50.0% of eltrombopag adverse event reports involve female patients and 41.2% involve male patients. The largest age group is elderly at 48%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.0%
Male41.2%
Unknown8.8%

Age group

< 20.7%
2–113.5%
12–173.0%
18–6444.9%
65+47.9%

What is eltrombopag used for

Conditions and purposes for which patients were taking eltrombopag when the adverse event was reported.

Abdominal DiscomfortAbdominal Pain UpperAccidental Exposure To Product By ChildAcquired Amegakaryocytic ThrombocytopeniaAcute Graft Versus Host Disease In SkinAcute Graft Versus Host Disease OralAcute Hepatitis BAcute Hepatitis CAcute Kidney InjuryAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAcute Myeloid Leukaemia (in Remission)Agranulocytosis

Showing 15 of 638 indications

Eltrombopag brand names and reporting trend

Eltrombopag is sold under brand names including Promacta, Eltrombopag, Alvaiz.

Brand names

Promacta8,836
Eltrombopag5,182
Alvaiz1

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking eltrombopag with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.