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Elranatamab Side Effects

The most commonly reported side effects of elranatamab include cytokine release syndrome, pyrexia, and death, based on 1,627 FDA adverse event reports from 2022 to 2025.

Elranatamab side effects

Percentages show how often each reaction appears relative to total reports for elranatamab.

1
Cytokine Release Syndrome18.3%297
2
Pyrexia7.1%116
3
Death7.1%116
4
Immune Effector Cell-associated Neurotoxicity Syndrome5.4%88
5
Pneumonia4.8%78
6
Malignant Neoplasm Progression4.1%66
7
Neutropenia3.7%61
8
Cytomegalovirus Infection Reactivation3.7%61
9
Infection3.7%60
10
Cytomegalovirus Infection3.6%59
11
Fatigue3.6%58
12
Plasma Cell Myeloma3.5%57
13
Diarrhoea3.4%55
14
Off Label Use3.3%54
15
Covid-193.1%50

These are voluntary reports and do not establish that elranatamab caused these reactions.

Report severity

89.9%Serious1,463 reports
45.9%Hospitalizations747 reports
22.5%Fatal366 reports

Seriousness is determined by the reporter, not by OpenClaim.

Elranatamab drug interactions

Other drugs that appear in adverse event reports alongside elranatamab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Daratumumab12.9%210
2
Dexamethasone6.9%112
3
Lenalidomide6.1%99
4
Acetaminophen3.6%59
5
Bortezomib1.5%24
6
Carfilzomib1.1%18
7
Tocilizumab1.0%17
8
Talquetamab-tgvs1.0%16
9
Ganciclovir0.9%15
10
Teclistamab-cqyv0.9%15
11
Diphenhydramine0.6%10
12
Cyclophosphamide0.6%9
13
Isatuximab-irfc0.5%8
14
Acyclovir0.5%8
15
Pomalidomide0.4%7

Taken alongside

1
Acyclovir17.8%289
2
Acetaminophen9.0%146
3
Dexamethasone7.1%116
4
Sulfamethoxazole5.9%96
5
Trimethoprim5.7%93
6
Omeprazole4.2%68
7
Diphenhydramine4.1%67
8
Lansoprazole3.7%61
9
Amlodipine3.7%60
10
Febuxostat3.0%49
11
Levofloxacin2.7%44
12
Aspirin2.6%43
13
Pantoprazole-sodium2.6%43
14
Loratadine2.4%39
15
Apixaban2.4%39

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports elranatamab side effects

40.5% of elranatamab adverse event reports involve female patients and 43.9% involve male patients. The largest age group is elderly at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.5%
Male43.9%
Unknown15.6%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6433.2%
65+66.8%

What is elranatamab used for

Conditions and purposes for which patients were taking elranatamab when the adverse event was reported.

AmyloidosisAnaemiaBone DisorderChronic Kidney DiseaseComaHead InjuryLight Chain DiseaseMalignant Neoplasm Of Unknown Primary SiteNeoplasm MalignantNodulePlasma Cell LeukaemiaPlasma Cell MyelomaPlasma Cell Myeloma RecurrentPlasma Cell Myeloma RefractoryPlasma Cells Increased

Showing 15 of 19 indications

Elranatamab brand names and reporting trend

Elranatamab is sold under the brand name Elrexfio.

Brand names

Elrexfio1,867

Quarterly reports (20222025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking elranatamab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.