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Elotuzumab Side Effects

The most commonly reported side effects of elotuzumab include plasma cell myeloma, pneumonia, and death, based on 5,084 FDA adverse event reports from 2010 to 2025. 3.8% of reports found the drug to be ineffective.

Elotuzumab side effects

Percentages show how often each reaction appears relative to total reports for elotuzumab.

1
Plasma Cell Myeloma10.9%556
2
Pneumonia5.9%301
3
Death5.9%299
4
Malignant Neoplasm Progression4.8%244
5
Fatigue4.6%233
6
Diarrhoea4.5%230
7
Pyrexia4.2%215
8
Drug Ineffective3.8%191
9
Neutropenia3.5%179
10
Anaemia3.3%168
11
Thrombocytopenia2.8%140
12
Platelet Count Decreased2.6%134
13
Off Label Use2.5%126
14
Neuropathy Peripheral2.3%115
15
Sepsis2.2%112

These are voluntary reports and do not establish that elotuzumab caused these reactions.

Report severity

81.4%Serious4,139 reports
39.6%Hospitalizations2,011 reports
17.9%Fatal910 reports

Seriousness is determined by the reporter, not by OpenClaim.

Elotuzumab drug interactions

Other drugs that appear in adverse event reports alongside elotuzumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide54.4%2,767
2
Dexamethasone43.8%2,228
3
Pomalidomide28.4%1,445
4
Carfilzomib11.8%600
5
Bortezomib11.3%572
6
Cyclophosphamide6.8%344
7
Daratumumab6.1%309
8
Thalidomide3.4%171
9
Melphalan2.8%144
10
Doxorubicin-hydrochloride2.7%139
11
Ixazomib-citrate2.3%116
12
Etoposide1.4%69
13
Selinexor1.2%62
14
Bendamustine-hydrochloride1.2%60
15
Cisplatin1.1%56

Taken alongside

1
Dexamethasone27.0%1,371
2
Aspirin19.7%1,002
3
Acyclovir17.4%884
4
Acetaminophen12.5%633
5
Omeprazole7.6%384
6
Zoledronic-acid7.5%382
7
Ergocalciferol6.9%352
8
Pantoprazole-sodium6.2%314
9
Ondansetron6.1%312
10
Furosemide6.1%310
11
Bortezomib6.1%309
12
Gabapentin6.0%307
13
Amlodipine5.6%283
14
Metoprolol5.6%283
15
Calcium5.5%280

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports elotuzumab side effects

38.7% of elotuzumab adverse event reports involve female patients and 47.8% involve male patients. The largest age group is elderly at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.7%
Male47.8%
Unknown13.5%

Age group

< 2<0.1%
2–110.0%
12–170.0%
18–6434.4%
65+65.6%

What is elotuzumab used for

Conditions and purposes for which patients were taking elotuzumab when the adverse event was reported.

Allogenic Stem Cell TransplantationAmyloidosisAphthous UlcerAmyloidosisAutologous Haematopoietic Stem Cell TransplantB-cell LymphomaBone LesionBone Marrow Conditioning RegimenBlood Pressure MeasurementBone LesionCardiac AmyloidosisCerebrovascular AccidentChemotherapyCovid-19Chemotherapy

Showing 15 of 57 indications

Elotuzumab brand names and reporting trend

Elotuzumab is sold under the brand name Empliciti.

Brand names

Empliciti3,583

Quarterly reports (20102025)

20102016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking elotuzumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.