OpenClaim

Eliglustat Side Effects

The most commonly reported side effects of eliglustat include weight increased, weight decreased, and product dose omission in error, based on 1,454 FDA adverse event reports from 2014 to 2025.

#1 Reported: Weight IncreasedAll side effects ↓Top Co-Medication: ImigluceraseDrug interactions ↓77% of Reports Are AdultDemographics ↓

Eliglustat side effects

Percentages show how often each reaction appears relative to total reports for eliglustat.

1
Weight Increased9.8%142
2
Weight Decreased8.4%122
3
Product Dose Omission In Error8.3%120
4
Product Dose Omission Issue5.2%76
5
Fatigue5.1%74
6
Arthralgia3.3%48
7
Nausea3.2%47
8
Dyspepsia3.2%46
9
Fall3.0%43
10
Covid-192.8%41
11
Dizziness2.8%40
12
Diarrhoea2.7%39
13
Product Dose Omission2.6%38
14
Condition Aggravated2.5%36
15
Headache2.4%35

These are voluntary reports and do not establish that eliglustat caused these reactions.

Report severity

29.8%Serious434 reports
13.3%Hospitalizations193 reports
1.4%Fatal20 reports

Seriousness is determined by the reporter, not by OpenClaim.

Eliglustat drug interactions

Other drugs that appear in adverse event reports alongside eliglustat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Imiglucerase2.5%37
2
Velaglucerase-alfa0.5%7
3
Amoxicillin0.2%3
4
Taliglucerase-alfa0.2%3
5
Miglustat0.2%3
6
Naproxen0.2%3
7
Risperidone0.2%3
8
Sodium-oxybate0.2%3
9
Zoledronic-acid0.2%3
10
Teriparatide0.2%3
11
Estradiol0.2%3
12
Cimetidine0.1%2
13
Metoprolol0.1%2
14
Sertraline-hydrochloride0.1%2
15
Diclofenac0.1%2

Taken alongside

1
Ergocalciferol5.1%74
2
Acetaminophen2.6%38
3
Levothyroxine-sodium2.4%35
4
Ibuprofen2.2%32
5
Omeprazole2.0%29
6
Imiglucerase1.7%25
7
Cetirizine-hydrochloride1.7%24
8
Aspirin1.5%22
9
Metformin1.4%21
10
Epinephrine1.4%21
11
Ascorbic-acid1.4%20
12
Atorvastatin-calcium1.2%18
13
Calcium1.2%18
14
Lisinopril1.1%16
15
Losartan-potassium1.0%15

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports eliglustat side effects

52.3% of eliglustat adverse event reports involve female patients and 39.2% involve male patients. The largest age group is adult at 77%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.3%
Male39.2%
Unknown8.5%

Age group

< 20.2%
2–111.5%
12–172.2%
18–6476.8%
65+19.4%

What is eliglustat used for

Conditions and purposes for which patients were taking eliglustat when the adverse event was reported.

Abdominal LymphadenopathyBone CancerChronic Hepatitis CColon CancerDermatitisFabry^s DiseaseGaucher^s DiseaseGaucher^s Disease Type IGaucher^s Disease Type IiiGaucher^s DiseaseGaucher^s Disease Type IGaucher^s Disease Type IiiHereditary DisorderHypertriglyceridaemiaIll-defined Disorder

Showing 15 of 33 indications

Eliglustat brand names and reporting trend

Quarterly reports (2014–2025)

20142016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking eliglustat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

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