OpenClaim

Eflornithine Side Effects

The most commonly reported side effects of eflornithine include product quality issue, rash, and hair growth abnormal, based on 737 FDA adverse event reports from 2004 to 2025. 23.2% of reports found the drug to be ineffective.

Eflornithine side effects

Percentages show how often each reaction appears relative to total reports for eflornithine.

1
Drug Ineffective23.2%171
2
Product Quality Issue6.1%45
3
Rash4.9%36
4
Hair Growth Abnormal4.6%34
5
Alopecia4.2%31
6
Condition Aggravated3.3%24
7
Off Label Use3.3%24
8
Seizure2.6%19
9
Hypotension2.4%18
10
Nausea2.3%17
11
Erythema2.3%17
12
Acne2.3%17
13
Arthralgia2.2%16
14
Anaemia2.2%16
15
Pain2.0%15

These are voluntary reports and do not establish that eflornithine caused these reactions.

Report severity

45.3%Serious334 reports
19.4%Hospitalizations143 reports
6.0%Fatal44 reports

Seriousness is determined by the reporter, not by OpenClaim.

Eflornithine drug interactions

Other drugs that appear in adverse event reports alongside eflornithine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate3.0%22
2
Ethinyl-estradiol2.8%21
3
Drospirenone2.7%20
4
Pantoprazole-sodium2.3%17
5
Ascorbic-acid2.3%17
6
Amoxicillin2.3%17
7
Ulipristal-acetate2.2%16
8
Metronidazole2.2%16
9
Pregabalin2.2%16
10
Spironolactone2.0%15
11
Minocycline-hydrochloride2.0%15
12
Lamotrigine2.0%15
13
Quetiapine-fumarate2.0%15
14
Magnesium-acetate-tetrahydrate1.9%14
15
Glutathione-disulfide1.9%14

Taken alongside

1
Acetaminophen10.4%77
2
Omeprazole8.7%64
3
Ergocalciferol8.7%64
4
Levothyroxine-sodium6.6%49
5
Aspirin6.4%47
6
Ibuprofen5.8%43
7
Metformin5.7%42
8
Prednisone5.6%41
9
Albuterol5.4%40
10
Cyanocobalamin5.4%40
11
Hydrochlorothiazide5.3%39
12
Spironolactone4.7%35
13
Atorvastatin-calcium4.6%34
14
Amlodipine4.6%34
15
Potassium-chloride4.5%33

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports eflornithine side effects

82.0% of eflornithine adverse event reports involve female patients and 13.4% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female82.0%
Male13.4%
Unknown4.6%

Age group

< 22.0%
2–118.0%
12–171.8%
18–6460.6%
65+27.7%

What is eflornithine used for

Conditions and purposes for which patients were taking eflornithine when the adverse event was reported.

AcneAfrican TrypanosomiasisAmmonia AbnormalAcute Hepatic FailureAdrenal Gland CancerAfrican TrypanosomiasisAlanine Aminotransferase IncreasedAspartate Aminotransferase IncreasedBarrett^s OesophagusBlood Bilirubin IncreasedBone CancerBrain Neoplasm MalignantBrain Stem GliomaChemotherapyCreatine Deficiency Syndrome

Showing 15 of 63 indications

Eflornithine brand names and reporting trend

Eflornithine is sold under the brand name Ornidyl.

Brand names

Ornidyl200

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking eflornithine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.