OpenClaim

Eflapegrastim Side Effects

The most commonly reported side effects of eflapegrastim include white blood cell count increased, pancytopenia, and asthenia, based on 31 FDA adverse event reports from 2022 to 2025.

Eflapegrastim side effects

Percentages show how often each reaction appears relative to total reports for eflapegrastim.

1
White Blood Cell Count Increased12.9%4
2
Pancytopenia9.7%3
3
Asthenia9.7%3
4
Diarrhoea9.7%3
5
Leukocytosis9.7%3
6
Thrombocytopenia6.5%2
7
Constipation6.5%2
8
Bone Pain6.5%2
9
Fatigue6.5%2
10
Abdominal Pain6.5%2
11
Death6.5%2
12
Nausea6.5%2
13
Vomiting6.5%2
14
Febrile Neutropenia6.5%2
15
Off Label Use6.5%2

These are voluntary reports and do not establish that eflapegrastim caused these reactions.

Report severity

58.1%Serious18 reports
32.3%Hospitalizations10 reports
16.1%Fatal5 reports

Seriousness is determined by the reporter, not by OpenClaim.

Eflapegrastim drug interactions

Other drugs that appear in adverse event reports alongside eflapegrastim. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Carboplatin12.9%4
2
Pembrolizumab6.5%2
3
Doxorubicin-hydrochloride6.5%2
4
Cyclophosphamide6.5%2
5
Rituximab6.5%2
6
Paclitaxel3.2%1
7
Elacestrant-hydrochloride3.2%1
8
Fluorouracil3.2%1
9
Cisplatin3.2%1
10
Pemetrexed3.2%1
11
Docetaxel3.2%1
12
Trastuzumab3.2%1
13
Pertuzumab3.2%1
14
Prednisone3.2%1
15
Epcoritamab-bysp3.2%1

Taken alongside

1
Palonosetron-hydrochloride19.4%6
2
Dexamethasone16.1%5
3
Ondansetron12.9%4
4
Acetaminophen12.9%4
5
Aprepitant12.9%4
6
Apixaban9.7%3
7
Levothyroxine-sodium9.7%3
8
Prochlorperazine9.7%3
9
Doxorubicin-hydrochloride9.7%3
10
Cyclophosphamide9.7%3
11
Furosemide9.7%3
12
Filgrastim9.7%3
13
Amlodipine6.5%2
14
Alendronate-sodium6.5%2
15
Ferrous-sulfate6.5%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports eflapegrastim side effects

45.2% of eflapegrastim adverse event reports involve female patients and 29.0% involve male patients. The largest age group is elderly at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.2%
Male29.0%
Unknown25.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6438.9%
65+61.1%

What is eflapegrastim used for

Conditions and purposes for which patients were taking eflapegrastim when the adverse event was reported.

Colony Stimulating Factor TherapyNeutropeniaProduct Used For Unknown IndicationProphylaxisVitamin D Deficiency

Eflapegrastim brand names and reporting trend

Eflapegrastim is sold under the brand name Rolvedon.

Brand names

Rolvedon3

Quarterly reports (20222025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking eflapegrastim with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.