OpenClaim

Efgartigimod Side Effects

The most commonly reported side effects of efgartigimod include myasthenia gravis, myasthenia gravis crisis, and fatigue, based on 4,177 FDA adverse event reports from 2004 to 2025. 5.1% of reports found the drug to be ineffective.

Efgartigimod side effects

Percentages show how often each reaction appears relative to total reports for efgartigimod.

1
Myasthenia Gravis20.0%837
2
Myasthenia Gravis Crisis10.9%454
3
Fatigue10.4%436
4
Dyspnoea7.5%312
5
Asthenia6.9%289
6
Fall5.7%240
7
Urinary Tract Infection5.3%221
8
Muscular Weakness5.2%219
9
Drug Ineffective5.1%215
10
Death5.0%207
11
Headache4.9%203
12
Dysphagia4.4%184
13
Symptom Recurrence4.4%182
14
Covid-194.3%178
15
Hospitalisation4.2%174

These are voluntary reports and do not establish that efgartigimod caused these reactions.

Report severity

92.3%Serious3,854 reports
48.5%Hospitalizations2,027 reports
9.7%Fatal405 reports

Seriousness is determined by the reporter, not by OpenClaim.

Efgartigimod drug interactions

Other drugs that appear in adverse event reports alongside efgartigimod. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Prednisone2.3%96
2
Eculizumab2.0%83
3
Rituximab1.4%60
4
Prednisolone1.3%55
5
Pyridostigmine-bromide1.2%51
6
Mycophenolate1.2%49
7
Ravulizumab-cwvz1.1%48
8
Azathioprine1.1%45
9
Zilucoplan-sodium1.0%42
10
Methotrexate0.5%21
11
Tacrolimus0.5%20
12
Fostamatinib-disodium0.4%16
13
Hyaluronidase0.4%15
14
Rozanolixizumab-noli0.4%15
15
Bortezomib0.3%12

Taken alongside

1
Pyridostigmine-bromide11.9%496
2
Prednisone10.3%430
3
Prednisolone4.0%166
4
Ergocalciferol3.3%136
5
Mycophenolate3.1%130
6
Epinephrine3.0%125
7
Sodium-chloride2.8%118
8
Azathioprine2.8%117
9
Diphenhydramine2.8%116
10
Tacrolimus2.5%106
11
Aspirin2.3%98
12
Acetaminophen2.1%89
13
Levothyroxine-sodium1.9%80
14
Amlodipine1.8%76
15
Atorvastatin-calcium1.8%74

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports efgartigimod side effects

15.3% of efgartigimod adverse event reports involve female patients and 12.0% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female15.3%
Male12.0%
Unknown72.7%

Age group

< 20.0%
2–110.2%
12–170.2%
18–6447.3%
65+52.3%

What is efgartigimod used for

Conditions and purposes for which patients were taking efgartigimod when the adverse event was reported.

Aplastic AnaemiaAcute Respiratory FailureAnti-gad AntibodyAnti-muscle Specific Kinase Antibody PositiveAnti-neutrophil Cytoplasmic Antibody Positive VasculitisAntiacetylcholine Receptor AntibodyAsthmaAutoimmune NodopathyChronic Inflammatory Demyelinating PolyradiculoneuropathyChronic Obstructive Pulmonary DiseaseDiabetic NephropathyEncephalitisEncephalitis AutoimmuneExposure During PregnancyEyelid Ptosis

Showing 15 of 53 indications

Efgartigimod brand names and reporting trend

Efgartigimod is sold under brand names including Vyvgart, Vyvgart Hytrulo.

Brand names

Vyvgart799
Vyvgart Hytrulo80

Quarterly reports (20042025)

2004201020152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking efgartigimod with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.