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Efavirenz Side Effects

The most commonly reported side effects of efavirenz include bone density decreased, chronic kidney disease, and tooth loss, based on 34,522 FDA adverse event reports from 2004 to 2025.

Efavirenz side effects

Percentages show how often each reaction appears relative to total reports for efavirenz.

1
Bone Density Decreased28.2%9,721
2
Chronic Kidney Disease17.8%6,128
3
Tooth Loss14.5%4,993
4
Renal Injury13.9%4,792
5
Renal Failure13.9%4,788
6
Pain13.5%4,668
7
Emotional Distress13.3%4,577
8
Bone Loss13.2%4,543
9
Anxiety12.8%4,405
10
Osteonecrosis12.8%4,402
11
Osteoporosis12.5%4,298
12
Skeletal Injury12.4%4,286
13
Multiple Fractures12.1%4,173
14
Anhedonia11.7%4,045
15
Osteopenia8.1%2,784

These are voluntary reports and do not establish that efavirenz caused these reactions.

Report severity

88.1%Serious30,413 reports
17.5%Hospitalizations6,047 reports
6.7%Fatal2,328 reports

Seriousness is determined by the reporter, not by OpenClaim.

Efavirenz drug interactions

Other drugs that appear in adverse event reports alongside efavirenz. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tenofovir68.5%23,659
2
Emtricitabine60.8%21,000
3
Lamivudine20.5%7,062
4
Cobicistat13.4%4,624
5
Elvitegravir13.4%4,624
6
Rilpivirine12.7%4,373
7
Zidovudine9.8%3,389
8
Ritonavir8.8%3,021
9
Lopinavir5.9%2,043
10
Abacavir5.5%1,908
11
Stavudine5.2%1,799
12
Raltegravir-potassium4.3%1,494
13
Nevirapine4.2%1,445
14
Didanosine3.9%1,347
15
Atazanavir-sulfate3.7%1,285

Taken alongside

1
Tenofovir33.5%11,581
2
Emtricitabine32.6%11,251
3
Bictegravir13.6%4,682
4
Cobicistat11.5%3,962
5
Elvitegravir9.8%3,385
6
Lamivudine8.8%3,042
7
Ritonavir4.7%1,624
8
Rilpivirine4.7%1,620
9
Abacavir4.1%1,406
10
Zidovudine4.0%1,389
11
Dolutegravir3.4%1,180
12
Darunavir3.2%1,119
13
Sulfamethoxazole3.2%1,111
14
Acetaminophen2.7%948
15
Trimethoprim2.6%912

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports efavirenz side effects

24.8% of efavirenz adverse event reports involve female patients and 59.2% involve male patients. The largest age group is adult at 91%. These figures reflect who reports side effects, not underlying risk.

Sex

Female24.8%
Male59.2%
Unknown16.0%

Age group

< 21.9%
2–111.0%
12–170.6%
18–6491.5%
65+5.1%

What is efavirenz used for

Conditions and purposes for which patients were taking efavirenz when the adverse event was reported.

Acquired Immuno Deficiency SyndromeAcquired Immunodeficiency SyndromeAcquired Immunodeficiency SyndromeAcute Hiv InfectionAids Related ComplicationAmyotrophic Lateral SclerosisAnal Cancer Stage 0AnosmiaAnti-infective TherapyAntibiotic ProphylaxisAntiretroviral TherapyAntiviral ProphylaxisAntiviral TreatmentAsthmaAsymptomatic Hiv Infection

Showing 15 of 181 indications

Efavirenz brand names and reporting trend

Efavirenz is sold under brand names including Sustiva, Efavirenz, Emtricitabine And Tenofovir Alafenamide.

Brand names

Sustiva12,951
Efavirenz, Emtricitabine And Tenofovir Alafenamide10

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking efavirenz with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.