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Edoxaban Side Effects

The most commonly reported side effects of edoxaban include dyspnoea, anaemia, and atrial fibrillation, based on 11,529 FDA adverse event reports from 2015 to 2025.

Edoxaban side effects

Percentages show how often each reaction appears relative to total reports for edoxaban.

1
Dyspnoea6.0%694
2
Anaemia5.9%682
3
Atrial Fibrillation4.4%502
4
Off Label Use4.0%465
5
General Physical Health Deterioration4.0%465
6
Nausea3.9%452
7
Renal Impairment3.8%433
8
Fatigue3.7%430
9
Acute Kidney Injury3.7%425
10
Diarrhoea3.7%425
11
Cardiac Failure3.7%424
12
Dizziness3.4%396
13
Fall3.4%388
14
Drug Interaction3.1%359
15
Gastrointestinal Haemorrhage2.9%337

These are voluntary reports and do not establish that edoxaban caused these reactions.

Report severity

93.5%Serious10,778 reports
55.3%Hospitalizations6,379 reports
12.6%Fatal1,454 reports

Seriousness is determined by the reporter, not by OpenClaim.

Edoxaban drug interactions

Other drugs that appear in adverse event reports alongside edoxaban. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bisoprolol-fumarate3.9%453
2
Valsartan2.5%291
3
Aspirin2.3%270
4
Gemfibrozil2.0%234
5
Dapagliflozin2.0%234
6
Furosemide2.0%233
7
Torsemide2.0%225
8
Amiodarone-hydrochloride1.9%215
9
Sacubitril1.8%206
10
Spironolactone1.8%205
11
Prednisolone1.7%198
12
Apixaban1.6%187
13
Amlodipine1.6%186
14
Metoprolol1.5%176
15
Atorvastatin-calcium1.5%174

Taken alongside

1
Bisoprolol-fumarate20.3%2,341
2
Furosemide13.6%1,569
3
Atorvastatin-calcium13.1%1,512
4
Pantoprazole-sodium9.1%1,053
5
Amlodipine8.5%976
6
Levothyroxine-sodium8.4%964
7
Acetaminophen8.0%922
8
Spironolactone7.5%866
9
Lansoprazole7.5%859
10
Omeprazole7.2%835
11
Metoprolol6.4%734
12
Metformin6.2%714
13
Allopurinol5.7%658
14
Ramipril5.6%644
15
Aspirin5.1%589

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports edoxaban side effects

39.1% of edoxaban adverse event reports involve female patients and 44.2% involve male patients. The largest age group is elderly at 83%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.1%
Male44.2%
Unknown16.7%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6416.8%
65+83.1%

What is edoxaban used for

Conditions and purposes for which patients were taking edoxaban when the adverse event was reported.

Acute Lymphocytic Leukaemia RecurrentAnalgesic TherapyAnticoagulant TherapyAntiplatelet TherapyAortic Valve ReplacementAortic Valve StenosisArrhythmiaArrhythmia ProphylaxisAtrial FibrillationAtrial FlutterAcute Coronary SyndromeAcute Kidney InjuryAcute Myocardial InfarctionAdverse Drug ReactionAdverse Event

Showing 15 of 306 indications

Edoxaban brand names and reporting trend

Edoxaban is sold under brand names including Edoxaban, Savaysa.

Brand names

Edoxaban6,236
Savaysa6,152

Quarterly reports (20152025)

20152016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking edoxaban with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.