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Dydrogesterone Side Effects

The most commonly reported side effects of dydrogesterone include maternal exposure during pregnancy, exposure during pregnancy, and off label use, based on 241 FDA adverse event reports from 2004 to 2025.

Dydrogesterone side effects

Percentages show how often each reaction appears relative to total reports for dydrogesterone.

1
Maternal Exposure During Pregnancy15.4%37
2
Exposure During Pregnancy11.2%27
3
Off Label Use6.6%16
4
Foetal Exposure During Pregnancy6.6%16
5
Premature Baby5.4%13
6
Low Birth Weight Baby5.0%12
7
Abortion Spontaneous4.6%11
8
Vaginal Haemorrhage4.6%11
9
Placenta Accreta4.6%11
10
Ovarian Hyperstimulation Syndrome4.6%11
11
Abdominal Pain4.1%10
12
Premature Delivery4.1%10
13
Product Use In Unapproved Indication4.1%10
14
Toxicity To Various Agents4.1%10
15
Pelvic Infection3.7%9

These are voluntary reports and do not establish that dydrogesterone caused these reactions.

Report severity

94.2%Serious227 reports
44.4%Hospitalizations107 reports
2.5%Fatal6 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dydrogesterone drug interactions

Other drugs that appear in adverse event reports alongside dydrogesterone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Estradiol15.4%37
2
Progesterone12.0%29
3
Aspirin9.1%22
4
Hydroxychloroquine-sulfate7.9%19
5
Prednisolone7.1%17
6
Follitropin-alfa-beta6.2%15
7
Tacrolimus6.2%15
8
Enoxaparin-sodium5.4%13
9
Letrozole5.4%13
10
Cyclosporine5.4%13
11
Metformin5.0%12
12
Acetaminophen4.6%11
13
Prednisone4.1%10
14
Methylprednisolone4.1%10
15
Choriogonadotropin-alfa4.1%10

Taken alongside

1
Estradiol14.1%34
2
Progesterone10.8%26
3
Folic-acid6.6%16
4
Levothyroxine-sodium6.2%15
5
Azathioprine4.6%11
6
Aspirin4.1%10
7
Cholecalciferol3.7%9
8
Methylprednisolone3.3%8
9
Prednisone3.3%8
10
Atorvastatin-calcium3.3%8
11
Alpha-tocopherol-acetate3.3%8
12
Pantoprazole-sodium2.9%7
13
Omeprazole2.5%6
14
Metoprolol2.5%6
15
Valproate-sodium2.1%5

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dydrogesterone side effects

83.8% of dydrogesterone adverse event reports involve female patients and 6.2% involve male patients. The largest age group is adult at 84%. These figures reflect who reports side effects, not underlying risk.

Sex

Female83.8%
Male6.2%
Unknown10.0%

Age group

< 27.8%
2–110.0%
12–175.9%
18–6484.3%
65+2.0%

What is dydrogesterone used for

Conditions and purposes for which patients were taking dydrogesterone when the adverse event was reported.

AdenomyosisAssisted FertilisationAbortion SpontaneousAbortion ThreatenedAdrenogenital SyndromeAmenorrhoeaAnembryonic GestationAssisted Reproductive TechnologyBlood Luteinising Hormone DecreasedBiliary CirrhosisCongenital Uterine AnomalyControlled Ovarian StimulationDrug Exposure During PregnancyDrug Use For Unknown IndicationDisseminated Tuberculosis

Showing 15 of 72 indications

Dydrogesterone brand names and reporting trend

Dydrogesterone is sold under the brand name Gynorest.

Brand names

Gynorest270

Quarterly reports (20042025)

2004201020202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dydrogesterone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.