OpenClaim

Duvelisib Side Effects

The most commonly reported side effects of duvelisib include product use in unapproved indication, diarrhoea, and death, based on 738 FDA adverse event reports from 2016 to 2025. 4.1% of reports found the drug to be ineffective.

Duvelisib side effects

Percentages show how often each reaction appears relative to total reports for duvelisib.

1
Product Use In Unapproved Indication23.2%171
2
Diarrhoea14.5%107
3
Death13.6%100
4
Fatigue10.4%77
5
Off Label Use9.2%68
6
Prescribed Underdose8.8%65
7
Nausea6.6%49
8
Malignant Neoplasm Progression5.4%40
9
Pneumonia5.4%40
10
Pyrexia5.1%38
11
Rash4.6%34
12
Hospitalisation4.6%34
13
Asthenia4.2%31
14
Disease Progression4.1%30
15
Drug Ineffective4.1%30

These are voluntary reports and do not establish that duvelisib caused these reactions.

Report severity

60.6%Serious447 reports
32.4%Hospitalizations239 reports
22.6%Fatal167 reports

Seriousness is determined by the reporter, not by OpenClaim.

Duvelisib drug interactions

Other drugs that appear in adverse event reports alongside duvelisib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab4.7%35
2
Cyclophosphamide4.6%34
3
Doxorubicin-hydrochloride4.1%30
4
Vincristine-sulfate3.9%29
5
Bendamustine-hydrochloride3.7%27
6
Prednisone3.7%27
7
Romidepsin2.6%19
8
Ruxolitinib2.4%18
9
Ibrutinib2.3%17
10
Gemcitabine2.2%16
11
Docetaxel2.2%16
12
Obinutuzumab2.0%15
13
Venetoclax2.0%15
14
Etoposide1.8%13
15
Nivolumab1.8%13

Taken alongside

1
Acyclovir11.9%88
2
Sulfamethoxazole8.7%64
3
Trimethoprim8.3%61
4
Allopurinol6.6%49
5
Aspirin5.7%42
6
Acetaminophen5.3%39
7
Ondansetron5.3%39
8
Ergocalciferol5.0%37
9
Omeprazole4.5%33
10
Levothyroxine-sodium4.3%32
11
Atorvastatin-calcium3.9%29
12
Metoprolol3.8%28
13
Albuterol3.3%24
14
Furosemide3.3%24
15
Tamsulosin-hydrochloride3.3%24

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports duvelisib side effects

14.0% of duvelisib adverse event reports involve female patients and 21.7% involve male patients. The largest age group is elderly at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female14.0%
Male21.7%
Unknown64.4%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6446.9%
65+53.1%

What is duvelisib used for

Conditions and purposes for which patients were taking duvelisib when the adverse event was reported.

Acute Lymphocytic LeukaemiaAdult T-cell Lymphoma/leukaemiaAnaemiaAnaemia Of Chronic DiseaseAnaplastic Large-cell LymphomaAngiocentric LymphomaAngioimmunoblastic T-cell LymphomaAngioimmunoblastic T-cell Lymphoma Stage IiiAplastic AnaemiaAdult T-cell Lymphoma/leukaemiaAnaplastic Large Cell Lymphoma T- And Null-cell TypesAnaplastic Large-cell LymphomaAngioimmunoblastic T-cell LymphomaAngioimmunoblastic T-cell Lymphoma Stage IiiB-cell Lymphoma

Showing 15 of 114 indications

Duvelisib brand names and reporting trend

Duvelisib is sold under the brand name Copiktra.

Brand names

Copiktra232

Quarterly reports (20162025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking duvelisib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.