OpenClaim

Durvalumab Side Effects

The most commonly reported side effects of durvalumab include death, malignant neoplasm progression, and pneumonitis, based on 17,474 FDA adverse event reports from 2013 to 2025.

Durvalumab side effects

Percentages show how often each reaction appears relative to total reports for durvalumab.

1
Death18.1%3,167
2
Malignant Neoplasm Progression8.0%1,391
3
Pneumonitis4.7%823
4
Radiation Pneumonitis4.5%793
5
Pyrexia3.3%575
6
Diarrhoea3.1%539
7
Off Label Use2.8%481
8
Dyspnoea2.5%440
9
Interstitial Lung Disease2.5%433
10
Pneumonia2.4%416
11
Fatigue2.2%388
12
Rash2.2%387
13
Neutrophil Count Decreased2.2%380
14
Asthenia2.1%364
15
Anaemia2.0%351

These are voluntary reports and do not establish that durvalumab caused these reactions.

Report severity

95.0%Serious16,602 reports
30.4%Hospitalizations5,309 reports
30.3%Fatal5,289 reports

Seriousness is determined by the reporter, not by OpenClaim.

Durvalumab drug interactions

Other drugs that appear in adverse event reports alongside durvalumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tremelimumab-actl16.1%2,818
2
Gemcitabine8.4%1,467
3
Paclitaxel7.3%1,279
4
Carboplatin7.1%1,238
5
Cisplatin5.8%1,019
6
Etoposide3.4%588
7
Atezolizumab1.9%325
8
Pembrolizumab1.6%275
9
Pemetrexed1.5%265
10
Nivolumab1.4%239
11
Olaparib1.1%188
12
Bevacizumab0.9%160
13
Ipilimumab0.8%139
14
Avelumab0.6%99
15
Lenvatinib-mesylate0.4%76

Taken alongside

1
Cisplatin5.7%1,000
2
Etoposide5.6%974
3
Carboplatin5.6%971
4
Gemcitabine4.1%719
5
Acetaminophen3.6%629
6
Dexamethasone2.6%451
7
Pantoprazole-sodium2.4%419
8
Amlodipine2.1%371
9
Atorvastatin-calcium2.1%364
10
Ondansetron2.0%342
11
Aspirin1.8%323
12
Prednisone1.8%321
13
Levothyroxine-sodium1.8%314
14
Paclitaxel1.7%292
15
Metformin1.6%278

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports durvalumab side effects

29.9% of durvalumab adverse event reports involve female patients and 54.2% involve male patients. The largest age group is elderly at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female29.9%
Male54.2%
Unknown15.9%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6438.6%
65+61.3%

What is durvalumab used for

Conditions and purposes for which patients were taking durvalumab when the adverse event was reported.

Acute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma PancreasAdenoid Cystic CarcinomaAdenosquamous Cell Lung CancerAdenosquamous Cell Lung Cancer Stage IiiAdjuvant TherapyAnal CancerAnal Squamous Cell CarcinomaAnaplastic Thyroid CancerAngiosarcomaAnxiety DisorderAbdominal Pain UpperAbnormal Loss Of Weight

Showing 15 of 477 indications

Durvalumab brand names and reporting trend

Durvalumab is sold under the brand name Imfinzi.

Brand names

Imfinzi10,276

Quarterly reports (20132025)

2013202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking durvalumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.