OpenClaim

Durlobactam Side Effects

The most commonly reported side effects of durlobactam include death, off label use, and pneumonia acinetobacter, based on 17 FDA adverse event reports from 2009 to 2025. 11.8% of reports found the drug to be ineffective.

Durlobactam side effects

Percentages show how often each reaction appears relative to total reports for durlobactam.

1
Death23.5%4
2
Off Label Use23.5%4
3
Drug Ineffective11.8%2
4
Pneumonia Acinetobacter11.8%2
5
Abdominal Pain Upper5.9%1
6
Headache5.9%1
7
Drug Hypersensitivity5.9%1
8
Drug-induced Liver Injury5.9%1
9
Cholestasis5.9%1
10
Chronic Kidney Disease5.9%1
11
Liver Function Test Increased5.9%1
12
Cardiac Failure Acute5.9%1
13
Acute Kidney Injury5.9%1
14
Enteritis5.9%1
15
Dysbiosis5.9%1

These are voluntary reports and do not establish that durlobactam caused these reactions.

Report severity

82.4%Serious14 reports
17.6%Hospitalizations3 reports
52.9%Fatal9 reports

Seriousness is determined by the reporter, not by OpenClaim.

Durlobactam drug interactions

Other drugs that appear in adverse event reports alongside durlobactam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sulbactam-sodium76.5%13
2
Esomeprazole11.8%2
3
Fluconazole5.9%1
4
Famotidine5.9%1
5
Propranolol-hydrochloride5.9%1
6
Rabeprazole-sodium5.9%1
7
Etodolac5.9%1
8
Divalproex-sodium5.9%1
9
Carbamazepine5.9%1
10
Tiagabine-hydrochloride5.9%1
11
Diazepam5.9%1
12
Lansoprazole5.9%1
13
Pantoprazole-sodium5.9%1

Taken alongside

1
Metoprolol17.6%3
2
Aspirin11.8%2
3
Meropenem11.8%2
4
Paroxetine5.9%1
5
Phenytoin5.9%1
6
Pioglitazone-hydrochloride5.9%1
7
Dicyclomine-hydrochloride5.9%1
8
Gabapentin5.9%1
9
Alprazolam5.9%1
10
Raloxifene-hydrochloride5.9%1
11
Trandolapril5.9%1
12
Fluoxetine-hydrochloride5.9%1
13
Bisoprolol-fumarate5.9%1
14
Insulin5.9%1
15
Aripiprazole5.9%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports durlobactam side effects

23.5% of durlobactam adverse event reports involve female patients and 5.9% involve male patients. The largest age group is adult at 100%. These figures reflect who reports side effects, not underlying risk.

Sex

Female23.5%
Male5.9%
Unknown70.6%

Age group

< 20.0%
2–110.0%
12–170.0%
18–64100.0%
65+0.0%

What is durlobactam used for

Conditions and purposes for which patients were taking durlobactam when the adverse event was reported.

Acinetobacter BacteraemiaAcinetobacter InfectionBack PainBurkholderia InfectionDevice Related InfectionHaemofiltrationOsteomyelitisPneumonia AcinetobacterPneumonia BacterialProduct Used For Unknown IndicationSkin Infection

Durlobactam brand names and reporting trend

Durlobactam is sold under the brand name Xacduro (copackaged).

Brand names

Xacduro (copackaged)4

Quarterly reports (20092025)

200920242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking durlobactam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.