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Dulaglutide Side Effects

The most commonly reported side effects of dulaglutide include nausea, injection site pain, and blood glucose increased, based on 85,892 FDA adverse event reports from 2011 to 2025. 4.1% of reports found the drug to be ineffective.

Dulaglutide side effects

Percentages show how often each reaction appears relative to total reports for dulaglutide.

1
Nausea11.7%10,021
2
Injection Site Pain11.4%9,799
3
Blood Glucose Increased11.4%9,771
4
Diarrhoea6.7%5,762
5
Incorrect Dose Administered6.3%5,445
6
Vomiting6.3%5,444
7
Inappropriate Schedule Of Product Administration4.4%3,808
8
Drug Ineffective4.1%3,526
9
Weight Decreased3.9%3,357
10
Decreased Appetite3.7%3,160
11
Injection Site Haemorrhage3.6%3,133
12
Extra Dose Administered3.6%3,108
13
Glycosylated Haemoglobin Increased3.4%2,908
14
Fatigue2.8%2,416
15
Accidental Underdose2.7%2,357

These are voluntary reports and do not establish that dulaglutide caused these reactions.

Report severity

25.4%Serious21,824 reports
11.8%Hospitalizations10,125 reports
1.9%Fatal1,592 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dulaglutide drug interactions

Other drugs that appear in adverse event reports alongside dulaglutide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Insulin4.9%4,191
2
Metformin2.2%1,917
3
Empagliflozin1.6%1,403
4
Semaglutide1.5%1,254
5
Tirzepatide0.7%593
6
Dupilumab0.6%536
7
Dapagliflozin0.5%401
8
Adalimumab0.4%370
9
Lenalidomide0.4%322
10
Liraglutide0.4%319
11
Evolocumab0.3%300
12
Exenatide-synthetic0.3%280
13
Canagliflozin0.3%228
14
Omeprazole0.3%226
15
Hydrochlorothiazide0.3%221

Taken alongside

1
Metformin19.5%16,722
2
Insulin12.0%10,272
3
Atorvastatin-calcium4.5%3,869
4
Empagliflozin3.6%3,056
5
Aspirin3.4%2,950
6
Glipizide3.0%2,586
7
Lisinopril2.7%2,340
8
Ergocalciferol2.6%2,223
9
Glimepiride2.5%2,154
10
Levothyroxine-sodium2.4%2,082
11
Amlodipine2.3%1,991
12
Omeprazole2.3%1,956
13
Gabapentin2.2%1,932
14
Metoprolol2.1%1,763
15
Rosuvastatin2.0%1,737

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dulaglutide side effects

51.8% of dulaglutide adverse event reports involve female patients and 37.9% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.8%
Male37.9%
Unknown10.3%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6456.6%
65+43.1%

What is dulaglutide used for

Conditions and purposes for which patients were taking dulaglutide when the adverse event was reported.

Abdominal Fat ApronAcute Kidney InjuryAnaphylactic ReactionAnkylosing SpondylitisAnxietyAppetite DisorderAutoimmune ThyroiditisAutonomic Nervous System ImbalanceAdverse Drug ReactionAdverse EventAlbuminuriaAnxietyAortic Valve DiseaseAppetite DisorderArrhythmia

Showing 15 of 253 indications

Dulaglutide brand names and reporting trend

Dulaglutide is sold under the brand name Trulicity.

Brand names

Trulicity2,455

Quarterly reports (20112025)

20112016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dulaglutide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.