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Droxidopa Side Effects

The most commonly reported side effects of droxidopa include dizziness, death, and blood pressure increased, based on 21,322 FDA adverse event reports from 2004 to 2025. 7.8% of reports found the drug to be ineffective.

Droxidopa side effects

Percentages show how often each reaction appears relative to total reports for droxidopa.

1
Dizziness13.6%2,903
2
Death10.1%2,152
3
Blood Pressure Increased8.8%1,880
4
Drug Ineffective7.8%1,657
5
Headache7.4%1,583
6
Fall7.0%1,491
7
Hypotension5.9%1,251
8
Fatigue5.6%1,192
9
Hypertension5.4%1,148
10
Nausea5.0%1,064
11
Blood Pressure Decreased4.7%1,012
12
Drug Dose Omission4.5%958
13
Loss Of Consciousness3.9%842
14
Malaise3.9%838
15
Blood Pressure Fluctuation3.6%763

These are voluntary reports and do not establish that droxidopa caused these reactions.

Report severity

38.5%Serious8,211 reports
15.7%Hospitalizations3,337 reports
13.1%Fatal2,790 reports

Seriousness is determined by the reporter, not by OpenClaim.

Droxidopa drug interactions

Other drugs that appear in adverse event reports alongside droxidopa. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pimavanserin1.9%415
2
Levodopa1.8%375
3
Carbidopa1.7%363
4
Midodrine-hydrochloride1.1%228
5
Fludrocortisone-acetate0.8%169
6
Amantadine0.3%66
7
Istradefylline0.3%57
8
Entacapone0.2%47
9
Pyridostigmine-bromide0.2%39
10
Lenalidomide0.2%35
11
Gabapentin0.2%34
12
Zonisamide0.1%27
13
Sodium-oxybate0.1%27
14
Rasagiline-mesylate0.1%27
15
Apomorphine-hydrochloride0.1%27

Taken alongside

1
Midodrine-hydrochloride6.6%1,404
2
Fludrocortisone-acetate6.2%1,330
3
Carbidopa6.0%1,269
4
Levodopa5.0%1,072
5
Aspirin4.1%877
6
Ergocalciferol3.8%818
7
Levothyroxine-sodium3.0%648
8
Atorvastatin-calcium3.0%631
9
Gabapentin2.8%601
10
Acetaminophen2.7%575
11
Omeprazole2.5%536
12
Clonazepam2.1%442
13
Cyanocobalamin1.9%413
14
Tamsulosin-hydrochloride1.7%353
15
Pantoprazole-sodium1.6%351

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports droxidopa side effects

45.5% of droxidopa adverse event reports involve female patients and 51.8% involve male patients. The largest age group is elderly at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.5%
Male51.8%
Unknown2.7%

Age group

< 2<0.1%
2–11<0.1%
12–170.5%
18–6431.2%
65+68.2%

What is droxidopa used for

Conditions and purposes for which patients were taking droxidopa when the adverse event was reported.

11-beta-hydroxylase DeficiencyAcute Respiratory FailureAdrenal DisorderAdrenal InsufficiencyAdrenocortical Insufficiency AcuteAffect LabilityAlcoholismAmyloidosisAmyotrophic Lateral SclerosisAnaemiaAngerAngiopathyAnxiety DisorderApraxiaArrhythmia

Showing 15 of 382 indications

Droxidopa brand names and reporting trend

Droxidopa is sold under the brand name Northera.

Brand names

Northera1,664

Quarterly reports (20042025)

2005201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking droxidopa with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.