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Drospirenone Side Effects

The most commonly reported side effects of drospirenone include pain, pain, and injury, based on 50,750 FDA adverse event reports from 2004 to 2025.

Drospirenone side effects

Percentages show how often each reaction appears relative to total reports for drospirenone.

1
Pain13.8%6,999
2
Pain11.9%6,031
3
Injury11.7%5,945
4
Pulmonary Embolism9.6%4,855
5
Injury9.5%4,838
6
Pulmonary Embolism8.9%4,538
7
Deep Vein Thrombosis8.8%4,465
8
Cholecystitis Chronic8.0%4,079
9
Deep Vein Thrombosis7.7%3,933
10
Anxiety7.1%3,618
11
Emotional Distress7.0%3,529
12
Anxiety6.9%3,478
13
Cholelithiasis6.2%3,167
14
Gallbladder Disorder6.2%3,129
15
Emotional Distress5.7%2,894

These are voluntary reports and do not establish that drospirenone caused these reactions.

Report severity

72.0%Serious36,532 reports
41.4%Hospitalizations21,035 reports
1.4%Fatal734 reports

Seriousness is determined by the reporter, not by OpenClaim.

Drospirenone drug interactions

Other drugs that appear in adverse event reports alongside drospirenone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ethinyl-estradiol81.4%41,304
2
Ulipristal-acetate7.7%3,922
3
Levomefolate-calcium3.1%1,588
4
Sodium-oxybate1.2%605
5
Estradiol0.8%408
6
Isotretinoin0.7%367
7
Levonorgestrel0.6%318
8
Adalimumab0.6%316
9
Dupilumab0.5%242
10
Estetrol0.4%191
11
Infliximab0.2%124
12
Sertraline-hydrochloride0.2%105
13
Bupropion0.2%102
14
Lamotrigine0.2%102
15
Fingolimod0.2%86

Taken alongside

1
Acetaminophen12.6%6,402
2
Ibuprofen11.2%5,661
3
Ethinyl-estradiol11.0%5,568
4
Hydrocodone7.1%3,619
5
Albuterol5.3%2,668
6
Levothyroxine-sodium4.3%2,160
7
Naproxen4.0%2,043
8
Omeprazole3.7%1,883
9
Oxycodone3.7%1,878
10
Fluticasone3.4%1,723
11
Promethazine-hydrochloride3.1%1,595
12
Azithromycin3.1%1,556
13
Sertraline-hydrochloride2.8%1,444
14
Alprazolam2.7%1,391
15
Amoxicillin2.6%1,340

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports drospirenone side effects

92.7% of drospirenone adverse event reports involve female patients and 0.2% involve male patients. The largest age group is adult at 93%. These figures reflect who reports side effects, not underlying risk.

Sex

Female92.7%
Male0.2%
Unknown7.1%

Age group

< 20.2%
2–110.1%
12–176.0%
18–6493.5%
65+0.1%

What is drospirenone used for

Conditions and purposes for which patients were taking drospirenone when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbnormal BehaviourAbnormal Uterine BleedingAccidental Drug Intake By ChildAcneAcne CysticAcne NosAdenomyosisAdnexa Uteri PainAdrenal InsufficiencyAdrenogenital Syndrome

Showing 15 of 466 indications

Drospirenone brand names and reporting trend

Drospirenone is sold under the brand name Yaz.

Brand names

Yaz1,081

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking drospirenone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.