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Droperidol Side Effects

The most commonly reported side effects of droperidol include anaphylactic shock, vomiting, and nausea, based on 1,744 FDA adverse event reports from 2004 to 2025. 2.9% of reports found the drug to be ineffective.

Droperidol side effects

Percentages show how often each reaction appears relative to total reports for droperidol.

1
Anaphylactic Shock5.7%100
2
Vomiting5.0%88
3
Nausea4.6%80
4
Drug Hypersensitivity4.4%76
5
Drug Interaction4.2%73
6
Hypotension3.8%67
7
Restlessness3.8%66
8
Off Label Use3.8%66
9
Fatigue3.2%56
10
Anaphylactic Reaction3.2%56
11
Drug Ineffective2.9%51
12
Cardiac Arrest2.6%46
13
C-reactive Protein Increased2.6%46
14
Back Pain2.6%45
15
Sepsis2.5%44

These are voluntary reports and do not establish that droperidol caused these reactions.

Report severity

90.1%Serious1,571 reports
43.6%Hospitalizations760 reports
11.2%Fatal196 reports

Seriousness is determined by the reporter, not by OpenClaim.

Droperidol drug interactions

Other drugs that appear in adverse event reports alongside droperidol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Propofol24.5%428
2
Dexamethasone17.0%297
3
Sufentanil-citrate15.9%278
4
Ketamine-hydrochloride13.4%233
5
Acetaminophen11.5%200
6
Ondansetron8.8%153
7
Midazolam8.4%147
8
Fentanyl8.2%143
9
Cefazolin-sodium8.0%140
10
Apomorphine-hydrochloride7.9%137
11
Rocuronium-bromide7.3%128
12
Lidocaine7.0%122
13
Ketoprofen6.9%121
14
Ropivacaine-hydrochloride6.1%107
15
Tramadol-hydrochloride5.9%103

Taken alongside

1
Acetaminophen16.6%290
2
Fentanyl15.8%275
3
Ondansetron11.8%205
4
Propofol9.9%173
5
Apomorphine-hydrochloride9.8%171
6
Dexamethasone8.4%147
7
Enoxaparin-sodium8.0%139
8
Hydromorphone-hydrochloride7.9%138
9
Lorazepam7.6%132
10
Furosemide7.2%126
11
Levothyroxine-sodium7.1%124
12
Lidocaine7.1%123
13
Pantoprazole-sodium6.7%117
14
Alprazolam5.7%100
15
Pregabalin5.2%91

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports droperidol side effects

59.6% of droperidol adverse event reports involve female patients and 33.1% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.6%
Male33.1%
Unknown7.3%

Age group

< 20.5%
2–111.6%
12–173.2%
18–6467.1%
65+27.6%

What is droperidol used for

Conditions and purposes for which patients were taking droperidol when the adverse event was reported.

Abdominal PainAbnormal BehaviourAcute Lymphocytic LeukaemiaAdverse EventAgitationAnaesthesiaAnaesthesia ProcedureAnalgesiaAnalgesic TherapyAngiopathyAntiemetic Supportive CareAnxietyAppendicectomyArteriovenous FistulaAsthma

Showing 15 of 146 indications

Droperidol brand names and reporting trend

Droperidol is sold under the brand name Innovar.

Brand names

Innovar1,897

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking droperidol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.