OpenClaim

Dorzolamide Side Effects

The most commonly reported side effects of dorzolamide include treatment failure, eye irritation, and ocular hyperaemia, based on 19,110 FDA adverse event reports from 2004 to 2025. 7.2% of reports found the drug to be ineffective.

Dorzolamide side effects

Percentages show how often each reaction appears relative to total reports for dorzolamide.

1
Treatment Failure11.4%2,186
2
Drug Ineffective7.2%1,367
3
Eye Irritation6.2%1,183
4
Ocular Hyperaemia4.5%856
5
Eye Pain4.3%822
6
Off Label Use4.1%784
7
Fatigue4.0%762
8
Vision Blurred3.2%608
9
Headache3.1%600
10
Death3.1%588
11
Hypersensitivity3.0%567
12
Intraocular Pressure Increased2.9%546
13
Eye Pruritus2.7%521
14
Pain2.6%491
15
Dyspnoea2.6%490

These are voluntary reports and do not establish that dorzolamide caused these reactions.

Report severity

50.8%Serious9,717 reports
20.5%Hospitalizations3,927 reports
6.5%Fatal1,235 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dorzolamide drug interactions

Other drugs that appear in adverse event reports alongside dorzolamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Timolol28.7%5,488
2
Latanoprost10.3%1,969
3
Brimonidine-tartrate9.8%1,872
4
Bimatoprost5.3%1,019
5
Travoprost3.7%700
6
Adalimumab3.2%602
7
Brinzolamide3.1%596
8
Lenalidomide2.9%559
9
Cenegermin-bkbj2.4%461
10
Infliximab1.7%320
11
Prednisone1.6%315
12
Metformin1.5%279
13
Omeprazole1.4%274
14
Methotrexate1.4%265
15
Aspirin1.3%257

Taken alongside

1
Timolol32.6%6,232
2
Latanoprost19.5%3,726
3
Brimonidine-tartrate15.5%2,957
4
Aspirin12.5%2,395
5
Acetaminophen9.8%1,868
6
Atorvastatin-calcium9.6%1,838
7
Amlodipine9.3%1,769
8
Ergocalciferol9.3%1,768
9
Levothyroxine-sodium8.6%1,645
10
Furosemide7.4%1,422
11
Bimatoprost6.7%1,286
12
Omeprazole6.6%1,267
13
Metoprolol6.3%1,209
14
Metformin5.7%1,080
15
Lisinopril5.4%1,024

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dorzolamide side effects

53.8% of dorzolamide adverse event reports involve female patients and 40.0% involve male patients. The largest age group is elderly at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.8%
Male40.0%
Unknown6.3%

Age group

< 20.5%
2–110.9%
12–170.5%
18–6423.8%
65+74.3%

What is dorzolamide used for

Conditions and purposes for which patients were taking dorzolamide when the adverse event was reported.

Abnormal Sensation In EyeAge-related Macular DegenerationAngle Closure GlaucomaAnkylosing SpondylitisApraxiaArthralgiaAutoimmune RetinopathyAdverse EventAge-related Macular DegenerationAngle Closure GlaucomaAntiinflammatory TherapyAsthenopiaBehcet's SyndromeBlepharospasmBlindness

Showing 15 of 259 indications

Dorzolamide brand names and reporting trend

Dorzolamide is sold under the brand name Trusopt.

Brand names

Trusopt65

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dorzolamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.