OpenClaim

Dornase Side Effects

The most commonly reported side effects of dornase include infective pulmonary exacerbation of cystic fibrosis, cystic fibrosis, and hospitalisation, based on 19,314 FDA adverse event reports from 2004 to 2025.

Dornase side effects

Percentages show how often each reaction appears relative to total reports for dornase.

1
Infective Pulmonary Exacerbation Of Cystic Fibrosis11.7%2,253
2
Cystic Fibrosis8.9%1,724
3
Hospitalisation6.7%1,296
4
Pneumonia6.1%1,179
5
Cough4.9%945
6
Off Label Use4.8%936
7
No Adverse Event4.8%919
8
Infection4.7%909
9
Dyspnoea4.4%854
10
Condition Aggravated3.1%601
11
Headache2.7%527
12
Pulmonary Function Test Decreased2.5%476
13
Death2.3%449
14
Malaise2.3%447
15
Influenza2.3%441

These are voluntary reports and do not establish that dornase caused these reactions.

Report severity

68.6%Serious13,244 reports
54.3%Hospitalizations10,486 reports
4.2%Fatal810 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dornase drug interactions

Other drugs that appear in adverse event reports alongside dornase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ivacaftor44.9%8,673
2
Lumacaftor14.7%2,839
3
Tobramycin13.6%2,621
4
Aztreonam13.5%2,608
5
Elexacaftor-ivacaftor-tezacaftor12.3%2,371
6
Lipase1.8%346
7
Pancrelipase-amylase1.8%341
8
Protease1.8%341
9
Albuterol1.4%270
10
Vancomycin0.7%139
11
Azithromycin0.7%131
12
Alteplase0.7%127
13
Dupilumab0.7%127
14
Budesonide0.6%125
15
Sodium-chloride0.6%119

Taken alongside

1
Albuterol43.7%8,436
2
Lipase42.2%8,155
3
Pancrelipase-amylase41.1%7,938
4
Protease41.1%7,937
5
Azithromycin23.4%4,511
6
Tobramycin22.8%4,402
7
Fluticasone21.9%4,233
8
Sodium-chloride20.6%3,978
9
Ergocalciferol18.2%3,507
10
Omeprazole13.6%2,629
11
Aztreonam12.5%2,421
12
Montelukast-sodium10.7%2,066
13
Budesonide9.9%1,905
14
Insulin9.4%1,806
15
Ivacaftor8.9%1,715

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dornase side effects

51.6% of dornase adverse event reports involve female patients and 42.5% involve male patients. The largest age group is adult at 59%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.6%
Male42.5%
Unknown5.9%

Age group

< 21.5%
2–1115.9%
12–1719.1%
18–6459.3%
65+4.2%

What is dornase used for

Conditions and purposes for which patients were taking dornase when the adverse event was reported.

Acquired Pyrimidine Metabolism DisorderAcute Respiratory FailureAirway Secretion Clearance TherapyAmyotrophic Lateral SclerosisAnaemiaArthritisAsthmaAtelectasisAcute Left Ventricular FailureAcute Respiratory Distress SyndromeAcute Respiratory FailureAcute SinusitisAdenoidal HypertrophyAdverse Drug ReactionAirway Secretion Clearance Therapy

Showing 15 of 367 indications

Dornase brand names and reporting trend

Dornase is sold under the brand name Pulmozyme.

Brand names

Pulmozyme998

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dornase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.