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Dordaviprone Side Effects

The most commonly reported side effects of dordaviprone include death, disease progression, and hydrocephalus, based on 33 FDA adverse event reports from 2009 to 2025. 3.0% of reports found the drug to be ineffective.

Dordaviprone side effects

Percentages show how often each reaction appears relative to total reports for dordaviprone.

1
Death24.2%8
2
Disease Progression12.1%4
3
Hydrocephalus12.1%4
4
Nausea9.1%3
5
Neoplasm Progression9.1%3
6
Thrombosis6.1%2
7
Product Temperature Excursion Issue6.1%2
8
Seizure6.1%2
9
Csf Shunt Operation6.1%2
10
Hospice Care6.1%2
11
Dissociation3.0%1
12
Drug Ineffective3.0%1
13
Flushing3.0%1
14
High Density Lipoprotein Abnormal3.0%1
15
Myocardial Infarction3.0%1

These are voluntary reports and do not establish that dordaviprone caused these reactions.

Report severity

72.7%Serious24 reports
24.2%Hospitalizations8 reports
36.4%Fatal12 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dordaviprone drug interactions

Other drugs that appear in adverse event reports alongside dordaviprone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Niacin3.0%1
2
Esomeprazole3.0%1
3
Adalimumab3.0%1
4
Disulfiram3.0%1

Taken alongside

1
Dexamethasone39.4%13
2
Ondansetron24.2%8
3
Levetiracetam18.2%6
4
Acetaminophen18.2%6
5
Atorvastatin-calcium12.1%4
6
Omeprazole12.1%4
7
Bevacizumab12.1%4
8
Prochlorperazine12.1%4
9
Buspirone-hydrochloride9.1%3
10
Pantoprazole-sodium9.1%3
11
Polyethylene-glycol-33509.1%3
12
Lorazepam9.1%3
13
Amlodipine9.1%3
14
Metoprolol6.1%2
15
Trazodone-hydrochloride6.1%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dordaviprone side effects

27.3% of dordaviprone adverse event reports involve female patients and 69.7% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female27.3%
Male69.7%
Unknown3.0%

Age group

< 20.0%
2–1114.3%
12–174.8%
18–6466.7%
65+14.3%

What is dordaviprone used for

Conditions and purposes for which patients were taking dordaviprone when the adverse event was reported.

Brain Neoplasm MalignantBrain Stem GliomaDrug Use For Unknown IndicationProduct Used For Unknown IndicationSupplementation Therapy

Dordaviprone brand names and reporting trend

Dordaviprone is sold under the brand name Modeyso.

Brand names

Modeyso6

Quarterly reports (20092025)

20092025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dordaviprone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.