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Doravirine Side Effects

The most commonly reported side effects of doravirine include pain, anxiety, and emotional distress, based on 1,006 FDA adverse event reports from 2010 to 2025. 4.5% of reports found the drug to be ineffective.

Doravirine side effects

Percentages show how often each reaction appears relative to total reports for doravirine.

1
Pain8.3%83
2
Anxiety8.3%83
3
Emotional Distress7.2%72
4
Death6.9%69
5
Anhedonia6.0%60
6
Nausea5.6%56
7
Chronic Kidney Disease5.2%52
8
Pathogen Resistance5.0%50
9
Drug Ineffective4.5%45
10
Drug Resistance4.3%43
11
Off Label Use4.0%40
12
Virologic Failure4.0%40
13
Treatment Noncompliance3.9%39
14
Product Dose Omission Issue3.8%38
15
Depression3.8%38

These are voluntary reports and do not establish that doravirine caused these reactions.

Report severity

79.9%Serious804 reports
24.1%Hospitalizations242 reports
9.3%Fatal94 reports

Seriousness is determined by the reporter, not by OpenClaim.

Doravirine drug interactions

Other drugs that appear in adverse event reports alongside doravirine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tenofovir47.8%481
2
Lamivudine32.3%325
3
Emtricitabine26.1%263
4
Dolutegravir20.5%206
5
Bictegravir10.4%105
6
Darunavir8.0%80
7
Rilpivirine7.5%75
8
Raltegravir-potassium6.4%64
9
Ritonavir6.3%63
10
Efavirenz6.1%61
11
Abacavir5.7%57
12
Cobicistat5.0%50
13
Etravirine4.3%43
14
Maraviroc3.6%36
15
Elvitegravir3.2%32

Taken alongside

1
Tenofovir20.7%208
2
Dolutegravir16.0%161
3
Emtricitabine15.7%158
4
Lamivudine13.1%132
5
Darunavir10.0%101
6
Cobicistat7.6%76
7
Ritonavir7.3%73
8
Bictegravir7.0%70
9
Raltegravir-potassium5.7%57
10
Atorvastatin-calcium5.5%55
11
Amlodipine5.2%52
12
Acetaminophen5.2%52
13
Ergocalciferol4.7%47
14
Albuterol4.7%47
15
Acyclovir4.5%45

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports doravirine side effects

23.1% of doravirine adverse event reports involve female patients and 62.0% involve male patients. The largest age group is adult at 79%. These figures reflect who reports side effects, not underlying risk.

Sex

Female23.1%
Male62.0%
Unknown14.9%

Age group

< 20.7%
2–110.0%
12–170.1%
18–6478.8%
65+20.4%

What is doravirine used for

Conditions and purposes for which patients were taking doravirine when the adverse event was reported.

Acquired Immunodeficiency SyndromeAcquired Immunodeficiency SyndromeAntiretroviral TherapyAntiviral TreatmentAsymptomatic Hiv InfectionCd4 Lymphocytes AbnormalDrug Use For Unknown IndicationDrug ResistanceHerpes SimplexHiv Antibody PositiveHiv InfectionHiv TestHiv Test PositiveHiv AntibodyHiv Infection

Showing 15 of 27 indications

Doravirine brand names and reporting trend

Doravirine is sold under the brand name Pifeltro.

Brand names

Pifeltro292

Quarterly reports (20102025)

2010202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking doravirine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.