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Donanemab Side Effects

The most commonly reported side effects of donanemab include amyloid related imaging abnormality-oedema/effusion, amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits, and infusion related reaction, based on 1,596 FDA adverse event reports from 2005 to 2025.

#1 Reported: Amyloid Related Imaging Abnormality-oedema/effusionAll side effects ↓Top Co-Medication: DexamethasoneDrug interactions ↓85% of Reports Are ElderlyDemographics ↓

Donanemab side effects

Percentages show how often each reaction appears relative to total reports for donanemab.

1
Amyloid Related Imaging Abnormality-oedema/effusion17.7%282
2
Amyloid Related Imaging Abnormality-microhaemorrhages And Haemosiderin Deposits13.4%214
3
Infusion Related Reaction11.0%176
4
Headache9.6%153
5
Amyloid Related Imaging Abnormalities6.3%101
6
Flushing6.3%100
7
Cerebral Haemorrhage5.6%89
8
Dizziness4.9%79
9
Nausea4.6%74
10
Dyspnoea4.3%68
11
Cerebral Microhaemorrhage3.9%62
12
Confusional State3.4%55
13
Chills3.4%54
14
Blood Pressure Increased3.0%48
15
Erythema2.9%46

These are voluntary reports and do not establish that donanemab caused these reactions.

Report severity

50.8%Serious811 reports
12.5%Hospitalizations199 reports
2.2%Fatal35 reports

Seriousness is determined by the reporter, not by OpenClaim.

Donanemab drug interactions

Other drugs that appear in adverse event reports alongside donanemab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone0.5%8
2
Dimethyl0.4%6
3
Tobramycin0.4%6
4
Calcium0.4%6
5
Diclofenac0.4%6
6
Terbinafine0.4%6
7
Ciprofloxacin0.4%6
8
Moxifloxacin-hydrochloride0.4%6
9
Neomycin-sulfate0.4%6
10
Memantine-hydrochloride0.3%4
11
Doxorubicin-hydrochloride0.3%4
12
Lecanemab-irmb0.2%3
13
Teriparatide0.1%2
14
Fingolimod0.1%2
15
Evolocumab0.1%2

Taken alongside

1
Donepezil-hydrochloride4.9%79
2
Acetaminophen3.9%62
3
Aspirin3.2%51
4
Diphenhydramine2.4%39
5
Memantine-hydrochloride2.3%37
6
Amlodipine2.1%34
7
Atorvastatin-calcium2.1%33
8
Levothyroxine-sodium1.9%31
9
Rosuvastatin1.7%27
10
Ergocalciferol1.5%24
11
Metoprolol1.3%21
12
Escitalopram-oxalate1.2%19
13
Metformin1.2%19
14
Methylprednisolone1.2%19
15
Simvastatin1.1%18

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports donanemab side effects

47.9% of donanemab adverse event reports involve female patients and 28.1% involve male patients. The largest age group is elderly at 85%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.9%
Male28.1%
Unknown23.9%

Age group

< 20.0%
2–110.1%
12–170.0%
18–6415.3%
65+84.6%

What is donanemab used for

Conditions and purposes for which patients were taking donanemab when the adverse event was reported.

ArthralgiaAmyloidosisAnaphylactic ReactionCognitive DisorderDepressionDementiaDementia Alzheimer^s TypeDementia Of The Alzheimer^s Type, With Depressed MoodMemory ImpairmentOsteoarthritisOsteoarthritisProduct Used For Unknown IndicationProduct Used For Unknown IndicationPseudostrokeRheumatoid Arthritis

Showing 15 of 16 indications

Donanemab brand names and reporting trend

Donanemab is sold under the brand name Kisunla.

Brand names

Kisunla110

Quarterly reports (2005–2025)

200520102025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking donanemab with another medication?

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