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Disulfiram Side Effects

The most commonly reported side effects of disulfiram include off label use, fatigue, and drug interaction, based on 1,909 FDA adverse event reports from 2004 to 2025. 4.3% of reports found the drug to be ineffective.

Disulfiram side effects

Percentages show how often each reaction appears relative to total reports for disulfiram.

1
Off Label Use7.0%133
2
Fatigue5.8%111
3
Drug Interaction5.8%110
4
Toxicity To Various Agents4.5%86
5
Drug Ineffective4.3%83
6
Nausea3.7%71
7
Drug Abuse3.1%60
8
Drug Interaction2.8%54
9
Confusional State2.6%50
10
Dizziness2.5%48
11
Malaise2.5%48
12
Drug-induced Liver Injury2.5%48
13
Anxiety2.5%47
14
Vomiting2.5%47
15
Intentional Overdose2.4%45

These are voluntary reports and do not establish that disulfiram caused these reactions.

Report severity

84.8%Serious1,619 reports
46.8%Hospitalizations893 reports
8.3%Fatal158 reports

Seriousness is determined by the reporter, not by OpenClaim.

Disulfiram drug interactions

Other drugs that appear in adverse event reports alongside disulfiram. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Naltrexone7.6%146
2
Quetiapine-fumarate6.9%131
3
Olanzapine4.0%76
4
Venlafaxine2.4%45
5
Aripiprazole2.3%43
6
Fluoxetine-hydrochloride2.2%42
7
Diazepam2.1%41
8
Escitalopram-oxalate2.1%41
9
Lorazepam2.1%40
10
Clonazepam2.0%39
11
Lamotrigine2.0%38
12
Pregabalin2.0%38
13
Gabapentin2.0%38
14
Clozapine1.9%36
15
Acetaminophen1.9%36

Taken alongside

1
Quetiapine-fumarate5.1%97
2
Gabapentin4.9%94
3
Amlodipine4.8%91
4
Acetaminophen4.5%86
5
Aspirin4.5%85
6
Sertraline-hydrochloride4.5%85
7
Trazodone-hydrochloride4.5%85
8
Omeprazole4.3%83
9
Venlafaxine4.0%77
10
Escitalopram-oxalate4.0%77
11
Naltrexone4.0%76
12
Bupropion3.9%74
13
Albuterol3.8%72
14
Clonazepam3.4%65
15
Olanzapine3.4%64

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports disulfiram side effects

34.3% of disulfiram adverse event reports involve female patients and 58.3% involve male patients. The largest age group is adult at 88%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.3%
Male58.3%
Unknown7.4%

Age group

< 21.4%
2–110.6%
12–170.3%
18–6487.6%
65+10.1%

What is disulfiram used for

Conditions and purposes for which patients were taking disulfiram when the adverse event was reported.

Abstains From AlcoholAccidental Exposure To Product By ChildAdjuvant TherapyAlcohol AbuseAlcohol DetoxificationAlcohol InteractionAlcohol PoisoningAlcohol ProblemAlcohol RehabilitationAlcohol UseAlcohol Use DisorderAlcohol Withdrawal SyndromeAlcoholicAlcoholismAttention Deficit/hyperactivity Disorder

Showing 15 of 84 indications

Disulfiram brand names and reporting trend

Disulfiram is sold under the brand name Disulfiram.

Brand names

Disulfiram1,297

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking disulfiram with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.