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Disopyramide Side Effects

The most commonly reported side effects of disopyramide include off label use, dyspnoea, and malaise, based on 1,650 FDA adverse event reports from 2004 to 2025. 10.7% of reports found the drug to be ineffective.

Disopyramide side effects

Percentages show how often each reaction appears relative to total reports for disopyramide.

1
Drug Ineffective10.7%176
2
Off Label Use5.3%88
3
Dyspnoea3.5%58
4
Malaise3.5%57
5
Atrial Fibrillation3.0%49
6
Fatigue2.8%47
7
Atrial Fibrillation2.7%45
8
Dizziness2.6%43
9
Headache2.2%37
10
Drug Ineffective For Unapproved Indication2.1%35
11
Product Use Issue2.1%34
12
Drug Interaction2.0%33
13
Drug Interaction2.0%33
14
Diarrhoea1.9%32
15
Electrocardiogram Qt Prolonged1.8%30

These are voluntary reports and do not establish that disopyramide caused these reactions.

Report severity

70.1%Serious1,157 reports
34.2%Hospitalizations565 reports
8.4%Fatal139 reports

Seriousness is determined by the reporter, not by OpenClaim.

Disopyramide drug interactions

Other drugs that appear in adverse event reports alongside disopyramide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metoprolol3.3%55
2
Verapamil-hydrochloride2.4%40
3
Mavacamten2.4%40
4
Ethambutol-hydrochloride2.2%36
5
Diltiazem1.9%32
6
Rifampin1.8%30
7
Isoniazid1.6%27
8
Apixaban1.6%27
9
Clarithromycin1.5%24
10
Dabigatran-etexilate-mesylate1.5%24
11
Amiodarone-hydrochloride1.3%22
12
Aspirin1.2%20
13
Furosemide1.2%19
14
Omeprazole1.1%18
15
Lansoprazole1.1%18

Taken alongside

1
Aspirin12.6%208
2
Metoprolol9.2%152
3
Furosemide8.4%139
4
Amlodipine7.4%122
5
Warfarin5.9%98
6
Acetaminophen5.8%95
7
Atorvastatin-calcium5.8%95
8
Levothyroxine-sodium5.5%91
9
Digoxin4.9%81
10
Omeprazole4.8%79
11
Verapamil-hydrochloride4.2%69
12
Atenolol3.6%60
13
Diltiazem3.2%53
14
Famotidine3.2%52
15
Lansoprazole3.2%52

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports disopyramide side effects

57.2% of disopyramide adverse event reports involve female patients and 34.1% involve male patients. The largest age group is elderly at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.2%
Male34.1%
Unknown8.7%

Age group

< 20.3%
2–110.7%
12–171.1%
18–6433.5%
65+64.5%

What is disopyramide used for

Conditions and purposes for which patients were taking disopyramide when the adverse event was reported.

Antibiotic ProphylaxisAnticoagulant TherapyArrhythmiaArrhythmia ProphylaxisArrhythmia SupraventricularAtrial FibrillationAtrial FlutterAtrial TachycardiaAutonomic DysreflexiaAdenocarcinoma GastricAdrenal DisorderAdverse Drug ReactionAortic Valve DiseaseArrhythmiaAtrial Fibrillation

Showing 15 of 123 indications

Disopyramide brand names and reporting trend

Disopyramide is sold under the brand name Norpace Cr.

Brand names

Norpace Cr1,095

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking disopyramide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.