OpenClaim

Diroximel Side Effects

The most commonly reported side effects of diroximel include flushing, multiple sclerosis, and multiple sclerosis relapse, based on 11,153 FDA adverse event reports from 2004 to 2025. 4.4% of reports found the drug to be ineffective.

Diroximel side effects

Percentages show how often each reaction appears relative to total reports for diroximel.

1
Flushing14.0%1,560
2
Multiple Sclerosis9.2%1,023
3
Multiple Sclerosis Relapse8.4%935
4
Diarrhoea7.6%852
5
Product Dose Omission Issue7.0%785
6
Fatigue6.7%745
7
Nausea6.5%729
8
Headache5.2%585
9
Pruritus5.1%573
10
Memory Impairment4.8%532
11
Fall4.7%520
12
Abdominal Discomfort4.5%504
13
Product Dose Omission In Error4.4%493
14
Drug Ineffective4.4%490
15
Abdominal Pain Upper4.1%458

These are voluntary reports and do not establish that diroximel caused these reactions.

Report severity

39.0%Serious4,352 reports
19.7%Hospitalizations2,198 reports
2.9%Fatal325 reports

Seriousness is determined by the reporter, not by OpenClaim.

Diroximel drug interactions

Other drugs that appear in adverse event reports alongside diroximel. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dalfampridine4.0%446
2
Dimethyl4.0%445
3
Teriflunomide0.9%105
4
Interferon0.8%90
5
Natalizumab0.7%78
6
Ocrelizumab0.5%51
7
Glatiramer-acetate0.2%27
8
Aspirin0.2%23
9
Dupilumab0.2%23
10
Rituximab0.2%22
11
Methylprednisolone0.2%19
12
Fingolimod0.2%18
13
Peginterferon0.2%18
14
Gabapentin0.1%12
15
Prednisone<0.1%11

Taken alongside

1
Ergocalciferol12.6%1,404
2
Gabapentin8.5%951
3
Baclofen6.2%696
4
Aspirin5.8%648
5
Atorvastatin-calcium4.9%541
6
Levothyroxine-sodium4.8%534
7
Acetaminophen4.4%489
8
Cyanocobalamin4.0%451
9
Lisinopril3.6%403
10
Duloxetine-hydrochloride3.2%361
11
Metformin3.2%358
12
Omeprazole3.1%350
13
Metoprolol3.1%349
14
Ibuprofen2.9%318
15
Ascorbic-acid2.7%299

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports diroximel side effects

77.7% of diroximel adverse event reports involve female patients and 20.8% involve male patients. The largest age group is adult at 80%. These figures reflect who reports side effects, not underlying risk.

Sex

Female77.7%
Male20.8%
Unknown1.6%

Age group

< 2<0.1%
2–110.0%
12–170.3%
18–6480.4%
65+19.3%

What is diroximel used for

Conditions and purposes for which patients were taking diroximel when the adverse event was reported.

Autoinflammatory DiseaseCentral Nervous System LesionChronic Obstructive Pulmonary DiseaseClinical Trial ParticipantClinically Isolated SyndromeGait DisturbanceHemiplegiaIllnessMultiple SclerosisMaternal Exposure Timing UnspecifiedMultiple SclerosisMultiple Sclerosis RelapsePrimary Progressive Multiple SclerosisProduct Used For Unknown IndicationPlasma Cell Myeloma Refractory

Showing 15 of 25 indications

Diroximel brand names and reporting trend

Diroximel is sold under the brand name Diroximel Fumarate.

Brand names

Diroximel Fumarate2

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking diroximel with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.