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Dirithromycin Side Effects

The most commonly reported side effects of dirithromycin include chest pain, drug hypersensitivity, and myocardial infarction, based on 27 FDA adverse event reports from 2004 to 2025.

Dirithromycin side effects

Percentages show how often each reaction appears relative to total reports for dirithromycin.

1
Chest Pain22.2%6
2
Drug Hypersensitivity22.2%6
3
Myocardial Infarction18.5%5
4
Mitral Valve Incompetence18.5%5
5
Hypertension14.8%4
6
Tricuspid Valve Incompetence14.8%4
7
Coronary Artery Disease11.1%3
8
Economic Problem11.1%3
9
Hypotension11.1%3
10
Multiple Injuries11.1%3
11
Dysphagia7.4%2
12
Feeling Abnormal7.4%2
13
Drug Hypersensitivity7.4%2
14
Fatigue7.4%2
15
Transient Ischaemic Attack7.4%2

These are voluntary reports and do not establish that dirithromycin caused these reactions.

Report severity

66.7%Serious18 reports
48.1%Hospitalizations13 reports
7.4%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dirithromycin drug interactions

Other drugs that appear in adverse event reports alongside dirithromycin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rofecoxib18.5%5
2
Amoxicillin14.8%4
3
Clavulanate-potassium14.8%4
4
Atorvastatin-calcium14.8%4
5
Topiramate14.8%4
6
Digoxin11.1%3
7
Divalproex-sodium11.1%3
8
Lansoprazole11.1%3
9
Montelukast-sodium11.1%3
10
Tizanidine-hydrochloride11.1%3
11
Olanzapine11.1%3
12
Rosuvastatin11.1%3
13
Levofloxacin7.4%2
14
Hydrocodone7.4%2
15
Acetaminophen7.4%2

Taken alongside

1
Azithromycin33.3%9
2
Acetaminophen25.9%7
3
Amoxicillin22.2%6
4
Sulfamethoxazole22.2%6
5
Trimethoprim22.2%6
6
Aspirin18.5%5
7
Cyclobenzaprine-hydrochloride18.5%5
8
Fluticasone18.5%5
9
Tramadol-hydrochloride14.8%4
10
Prednisone14.8%4
11
Omeprazole14.8%4
12
Albuterol14.8%4
13
Clarithromycin14.8%4
14
Cephalexin14.8%4
15
Mometasone-furoate14.8%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dirithromycin side effects

55.6% of dirithromycin adverse event reports involve female patients and 33.3% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.6%
Male33.3%
Unknown11.1%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6466.7%
65+33.3%

What is dirithromycin used for

Conditions and purposes for which patients were taking dirithromycin when the adverse event was reported.

HypersensitivityProduct Used For Unknown IndicationSkin Test

Dirithromycin brand names and reporting trend

Dirithromycin is sold under the brand name Dynabac.

Brand names

Dynabac7

Quarterly reports (20042025)

200420052020

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dirithromycin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.