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Dipivefrin Side Effects

The most commonly reported side effects of dipivefrin include rash, vision blurred, and drug interaction, based on 57 FDA adverse event reports from 2004 to 2025. 7.0% of reports found the drug to be ineffective.

Dipivefrin side effects

Percentages show how often each reaction appears relative to total reports for dipivefrin.

1
Rash8.8%5
2
Vision Blurred8.8%5
3
Drug Interaction7.0%4
4
Drug Ineffective7.0%4
5
Nausea5.3%3
6
Visual Acuity Reduced5.3%3
7
Pneumonia5.3%3
8
Headache3.5%2
9
Intracranial Pressure Increased3.5%2
10
Hypersensitivity3.5%2
11
Hepatic Steatosis3.5%2
12
Asthenia3.5%2
13
Cerebral Atrophy3.5%2
14
Dyspnoea3.5%2
15
Anaemia3.5%2

These are voluntary reports and do not establish that dipivefrin caused these reactions.

Report severity

77.2%Serious44 reports
33.3%Hospitalizations19 reports
10.5%Fatal6 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dipivefrin drug interactions

Other drugs that appear in adverse event reports alongside dipivefrin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Latanoprost8.8%5
2
Quetiapine-fumarate8.8%5
3
Amiodarone-hydrochloride5.3%3
4
Fluorouracil5.3%3
5
Erlotinib-hydrochloride5.3%3
6
Timolol5.3%3
7
Tiotropium-bromide5.3%3
8
Adalimumab5.3%3
9
Leucovorin-calcium3.5%2
10
Acetazolamide3.5%2
11
Lenalidomide3.5%2
12
Naproxen1.8%1
13
Atorvastatin-calcium1.8%1
14
Ticlopidine-hydrochloride1.8%1
15
Venlafaxine1.8%1

Taken alongside

1
Timolol24.6%14
2
Dorzolamide-hydrochloride15.8%9
3
Aspirin14.0%8
4
Albuterol10.5%6
5
Brimonidine-tartrate10.5%6
6
Latanoprost10.5%6
7
Omeprazole10.5%6
8
Metoprolol8.8%5
9
Ergocalciferol8.8%5
10
Acetaminophen7.0%4
11
Levothyroxine-sodium7.0%4
12
Prednisone7.0%4
13
Divalproex-sodium7.0%4
14
Furosemide7.0%4
15
Alendronate-sodium7.0%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dipivefrin side effects

56.1% of dipivefrin adverse event reports involve female patients and 40.4% involve male patients. The largest age group is elderly at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.1%
Male40.4%
Unknown3.5%

Age group

< 20.0%
2–112.4%
12–170.0%
18–6446.3%
65+51.2%

What is dipivefrin used for

Conditions and purposes for which patients were taking dipivefrin when the adverse event was reported.

Bipolar DisorderDepressionDilatation PupillaryEye DisorderEye Lubrication TherapyGlaucomaHypersensitivityIntraocular Pressure IncreasedManiaMood SwingsProduct Used For Unknown IndicationProphylaxis

Dipivefrin brand names and reporting trend

Dipivefrin is sold under the brand name Akpro.

Brand names

Akpro2

Quarterly reports (20042025)

200420052025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dipivefrin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.