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Diphenylpyraline Side Effects

The most commonly reported side effects of diphenylpyraline include pain in extremity, gait disturbance, and fatigue, based on 21 FDA adverse event reports from 2004 to 2025.

Diphenylpyraline side effects

Percentages show how often each reaction appears relative to total reports for diphenylpyraline.

1
Pain In Extremity14.3%3
2
Gait Disturbance14.3%3
3
Fatigue14.3%3
4
Dizziness9.5%2
5
Vomiting9.5%2
6
Anaemia9.5%2
7
Arthralgia9.5%2
8
Depressed Mood9.5%2
9
Weight Increased9.5%2
10
Death9.5%2
11
Depression9.5%2
12
Anxiety9.5%2
13
Hypoaesthesia9.5%2
14
Paraesthesia9.5%2
15
Headache9.5%2

These are voluntary reports and do not establish that diphenylpyraline caused these reactions.

Report severity

81.0%Serious17 reports
38.1%Hospitalizations8 reports
19.0%Fatal4 reports

Seriousness is determined by the reporter, not by OpenClaim.

Diphenylpyraline drug interactions

Other drugs that appear in adverse event reports alongside diphenylpyraline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Valsartan14.3%3
2
Hydrochlorothiazide9.5%2
3
Zoledronic-acid9.5%2
4
Adalimumab9.5%2
5
Quetiapine-fumarate4.8%1
6
Promethazine-hydrochloride4.8%1
7
Alcohol4.8%1
8
Duloxetine-hydrochloride4.8%1
9
Niacin4.8%1
10
Rosuvastatin4.8%1
11
Esomeprazole4.8%1
12
Goserelin4.8%1
13
Citalopram-hydrobromide4.8%1
14
Denosumab4.8%1
15
Indacaterol-maleate4.8%1

Taken alongside

1
Levothyroxine-sodium14.3%3
2
Lansoprazole9.5%2
3
Prednisone9.5%2
4
Escitalopram-oxalate9.5%2
5
Ipratropium-bromide9.5%2
6
Risperidone4.8%1
7
Diazepam4.8%1
8
Nalbuphine-hydrochloride4.8%1
9
Rabeprazole-sodium4.8%1
10
Clopidogrel-bisulfate4.8%1
11
Nitroglycerin4.8%1
12
Ergocalciferol4.8%1
13
Aspirin4.8%1
14
Lisinopril4.8%1
15
Metformin4.8%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports diphenylpyraline side effects

52.4% of diphenylpyraline adverse event reports involve female patients and 47.6% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.4%
Male47.6%
Unknown0.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6452.9%
65+47.1%

What is diphenylpyraline used for

Conditions and purposes for which patients were taking diphenylpyraline when the adverse event was reported.

Abdominal DiscomfortAsthmatic CrisisConstipationCrohn's DiseaseHypersensitivityInflammationMigraineMultiple Sclerosis RelapseNeoplasm MalignantProduct Used For Unknown IndicationPainRheumatoid ArthritisVenous Insufficiency

Diphenylpyraline brand names and reporting trend

Diphenylpyraline is sold under the brand name Hispril.

Brand names

Hispril23

Quarterly reports (20042025)

20042025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking diphenylpyraline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.