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Dihydroergotamine Side Effects

The most commonly reported side effects of dihydroergotamine include nausea, off label use, and hyperhidrosis, based on 3,012 FDA adverse event reports from 2004 to 2025. 23.6% of reports found the drug to be ineffective.

Dihydroergotamine side effects

Percentages show how often each reaction appears relative to total reports for dihydroergotamine.

1
Drug Ineffective23.6%710
2
Nausea16.3%492
3
Off Label Use15.6%471
4
Hyperhidrosis12.5%378
5
Sedation11.9%358
6
Nightmare11.9%357
7
Product Use In Unapproved Indication10.9%327
8
Nephrolithiasis9.4%283
9
Migraine6.2%188
10
Dyspnoea4.9%149
11
Headache4.8%145
12
Fatigue4.3%131
13
Diarrhoea3.9%116
14
Cough3.6%107
15
Treatment Failure3.5%105

These are voluntary reports and do not establish that dihydroergotamine caused these reactions.

Report severity

72.5%Serious2,185 reports
33.4%Hospitalizations1,006 reports
6.0%Fatal181 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dihydroergotamine drug interactions

Other drugs that appear in adverse event reports alongside dihydroergotamine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Topiramate17.9%540
2
Amitriptyline-hydrochloride15.8%476
3
Propranolol-hydrochloride15.6%469
4
Gabapentin15.5%468
5
Rizatriptan-benzoate15.3%461
6
Ibuprofen15.2%458
7
Venlafaxine15.1%455
8
Acetaminophen14.0%422
9
Nortriptyline-hydrochloride13.7%414
10
Diclofenac13.6%411
11
Hydrochlorothiazide12.1%365
12
Celecoxib12.1%364
13
Ketamine-hydrochloride12.1%363
14
Ondansetron12.0%361
15
Meperidine-hydrochloride12.0%360

Taken alongside

1
Lidocaine20.7%624
2
Heparin19.9%599
3
Acetaminophen13.1%394
4
Pantoprazole-sodium7.7%232
5
Aspirin7.4%224
6
Ondansetron7.2%216
7
Gabapentin6.7%201
8
Ibuprofen6.4%194
9
Topiramate6.3%189
10
Omeprazole6.0%180
11
Levothyroxine-sodium5.8%176
12
Ergocalciferol5.8%174
13
Amitriptyline-hydrochloride5.7%173
14
Promethazine-hydrochloride4.9%147
15
Sumatriptan4.6%139

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dihydroergotamine side effects

53.9% of dihydroergotamine adverse event reports involve female patients and 27.8% involve male patients. The largest age group is adult at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.9%
Male27.8%
Unknown18.4%

Age group

< 20.7%
2–110.4%
12–171.7%
18–6475.0%
65+22.3%

What is dihydroergotamine used for

Conditions and purposes for which patients were taking dihydroergotamine when the adverse event was reported.

Anticoagulant TherapyAtrial FibrillationAtrial FlutterAnticoagulant TherapyBedriddenBlood Pressure FluctuationBursa RemovalCardiovascular DisorderChemotherapyCluster HeadacheCluster HeadachesCoagulopathyConfusional StateCoronary Artery DiseaseCluster Headache

Showing 15 of 99 indications

Dihydroergotamine brand names and reporting trend

Dihydroergotamine is sold under the brand name Trudhesa.

Brand names

Trudhesa340

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dihydroergotamine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.