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Digoxin Side Effects

The most commonly reported side effects of digoxin include dyspnoea, fatigue, and nausea, based on 75,361 FDA adverse event reports from 2004 to 2025.

Digoxin side effects

Percentages show how often each reaction appears relative to total reports for digoxin.

1
Dyspnoea5.2%3,936
2
Fatigue3.6%2,744
3
Nausea3.4%2,582
4
Diarrhoea3.4%2,579
5
Dyspnoea3.2%2,409
6
Nausea3.2%2,390
7
Dizziness3.1%2,348
8
Death3.1%2,333
9
Dizziness3.0%2,240
10
Atrial Fibrillation2.8%2,124
11
Drug Interaction2.7%2,042
12
Atrial Fibrillation2.7%2,025
13
Toxicity To Various Agents2.7%2,017
14
Asthenia2.6%1,958
15
Vomiting2.6%1,922

These are voluntary reports and do not establish that digoxin caused these reactions.

Report severity

83.3%Serious62,787 reports
51.2%Hospitalizations38,619 reports
19.4%Fatal14,608 reports

Seriousness is determined by the reporter, not by OpenClaim.

Digoxin drug interactions

Other drugs that appear in adverse event reports alongside digoxin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dabigatran-etexilate-mesylate4.6%3,472
2
Warfarin4.5%3,376
3
Furosemide4.3%3,261
4
Apixaban3.7%2,761
5
Rivaroxaban3.6%2,735
6
Treprostinil3.3%2,451
7
Ambrisentan2.6%1,962
8
Lenalidomide2.6%1,939
9
Amiodarone-hydrochloride2.5%1,897
10
Aspirin2.4%1,812
11
Bisoprolol-fumarate2.4%1,781
12
Valsartan2.1%1,571
13
Spironolactone2.0%1,474
14
Metoprolol1.8%1,385
15
Metformin1.8%1,374

Taken alongside

1
Furosemide33.5%25,218
2
Warfarin19.7%14,868
3
Aspirin17.7%13,328
4
Metoprolol16.8%12,636
5
Spironolactone13.1%9,889
6
Acetaminophen12.9%9,716
7
Atorvastatin-calcium12.1%9,090
8
Levothyroxine-sodium11.6%8,778
9
Carvedilol10.6%8,021
10
Omeprazole10.5%7,943
11
Simvastatin9.4%7,107
12
Lisinopril9.4%7,090
13
Potassium-chloride9.1%6,838
14
Albuterol9.1%6,824
15
Metformin8.7%6,536

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports digoxin side effects

50.3% of digoxin adverse event reports involve female patients and 44.1% involve male patients. The largest age group is elderly at 72%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.3%
Male44.1%
Unknown5.6%

Age group

< 21.2%
2–110.5%
12–170.5%
18–6425.3%
65+72.4%

What is digoxin used for

Conditions and purposes for which patients were taking digoxin when the adverse event was reported.

AbortionAbortion InducedAccidental Exposure To ProductAcral Lentiginous MelanomaAcute Coronary SyndromeAcute Kidney InjuryAcute Myeloid LeukaemiaAcute Myocardial InfarctionAcute Pulmonary OedemaAdenovirus InfectionAdverse Drug ReactionAdverse EventAfibAge-related Macular DegenerationAlveolar Capillary Dysplasia

Showing 15 of 633 indications

Digoxin brand names and reporting trend

Digoxin is sold under the brand name Lanoxicaps.

Brand names

Lanoxicaps70,682

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking digoxin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.