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Digitoxin Side Effects

The most commonly reported side effects of digitoxin include general physical health deterioration, dyspnoea, and atrial fibrillation, based on 3,223 FDA adverse event reports from 2004 to 2025.

Digitoxin side effects

Percentages show how often each reaction appears relative to total reports for digitoxin.

1
General Physical Health Deterioration10.0%321
2
Dyspnoea9.6%308
3
Atrial Fibrillation8.0%258
4
Anaemia6.5%211
5
Drug Interaction6.5%208
6
Dizziness6.5%208
7
Fall6.0%192
8
Bradycardia5.4%173
9
Oedema Peripheral5.0%161
10
Cardiac Failure4.2%135
11
Diarrhoea4.2%134
12
Haematochezia3.8%124
13
Acute Kidney Injury3.8%123
14
Fatigue3.5%112
15
Syncope3.4%108

These are voluntary reports and do not establish that digitoxin caused these reactions.

Report severity

99.0%Serious3,190 reports
78.0%Hospitalizations2,513 reports
17.6%Fatal566 reports

Seriousness is determined by the reporter, not by OpenClaim.

Digitoxin drug interactions

Other drugs that appear in adverse event reports alongside digitoxin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metoprolol11.3%365
2
Ramipril7.3%235
3
Phentermine6.5%209
4
Torsemide5.9%190
5
Bisoprolol-fumarate5.7%185
6
Apixaban5.5%178
7
Furosemide5.5%176
8
Spironolactone5.3%170
9
Rivaroxaban5.2%166
10
Valsartan5.1%165
11
Aspirin5.1%164
12
Amlodipine4.5%145
13
Pantoprazole-sodium4.2%135
14
Metformin3.5%112
15
Gemfibrozil3.4%108

Taken alongside

1
Metoprolol24.0%772
2
Pantoprazole-sodium21.3%685
3
Phentermine16.5%533
4
Ramipril15.8%509
5
Allopurinol14.7%474
6
Bisoprolol-fumarate14.4%465
7
Simvastatin13.0%418
8
Furosemide12.5%403
9
Aspirin12.2%393
10
Insulin11.5%371
11
Levothyroxine-sodium11.1%358
12
Spironolactone10.4%335
13
Torsemide10.2%330
14
Atorvastatin-calcium9.9%319
15
Apixaban9.2%297

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports digitoxin side effects

48.4% of digitoxin adverse event reports involve female patients and 46.9% involve male patients. The largest age group is elderly at 87%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.4%
Male46.9%
Unknown4.7%

Age group

< 20.4%
2–110.1%
12–170.3%
18–6412.3%
65+87.0%

What is digitoxin used for

Conditions and purposes for which patients were taking digitoxin when the adverse event was reported.

Accidental ExposureAortic SurgeryArrhythmiaArrhythmia ProphylaxisArteriosclerosis Coronary ArteryAtrial FibrillationAtrial FlutterAtrial TachycardiaArrhythmiaAtrial FibrillationAtrial TachycardiaCardiac DisorderCardiac FailureCardiac Failure ChronicCardiac Failure Congestive

Showing 15 of 60 indications

Digitoxin brand names and reporting trend

Digitoxin is sold under the brand name Crystodigin.

Brand names

Crystodigin3,448

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking digitoxin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.