OpenClaim

Diflunisal Side Effects

The most commonly reported side effects of diflunisal include fatigue, nausea, and drug hypersensitivity, based on 808 FDA adverse event reports from 2004 to 2025. 4.3% of reports found the drug to be ineffective.

Diflunisal side effects

Percentages show how often each reaction appears relative to total reports for diflunisal.

1
Fatigue5.9%48
2
Nausea5.8%47
3
Drug Hypersensitivity5.4%44
4
Pain5.2%42
5
Arthralgia4.3%35
6
Drug Ineffective4.3%35
7
Platelet Count Decreased3.8%31
8
Headache3.7%30
9
Diarrhoea3.5%28
10
Chronic Kidney Disease3.2%26
11
Malaise3.1%25
12
Urine Protein/creatinine Ratio Increased2.8%23
13
Fall2.7%22
14
Injection Site Pain2.6%21
15
Dizziness2.6%21

These are voluntary reports and do not establish that diflunisal caused these reactions.

Report severity

58.8%Serious475 reports
29.1%Hospitalizations235 reports
8.3%Fatal67 reports

Seriousness is determined by the reporter, not by OpenClaim.

Diflunisal drug interactions

Other drugs that appear in adverse event reports alongside diflunisal. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Inotersen-sodium10.6%86
2
Adalimumab8.8%71
3
Etanercept5.7%46
4
Naproxen4.1%33
5
Patisiran-sodium4.0%32
6
Ibuprofen3.3%27
7
Acetaminophen3.2%26
8
Diclofenac2.8%23
9
Aspirin2.8%23
10
Esomeprazole2.7%22
11
Oxycodone2.6%21
12
Sodium-oxybate2.6%21
13
Ciprofloxacin2.2%18
14
Omeprazole2.2%18
15
Tramadol-hydrochloride2.2%18

Taken alongside

1
Acetaminophen19.2%155
2
Omeprazole17.0%137
3
Ergocalciferol16.0%129
4
Aspirin15.3%124
5
Gabapentin13.6%110
6
Levothyroxine-sodium12.1%98
7
Prednisone11.9%96
8
Furosemide11.1%90
9
Atorvastatin-calcium10.8%87
10
Hydrochlorothiazide10.3%83
11
Albuterol9.5%77
12
Folic-acid9.4%76
13
Metoprolol9.3%75
14
Hydrocodone9.2%74
15
Lisinopril8.9%72

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports diflunisal side effects

58.8% of diflunisal adverse event reports involve female patients and 26.0% involve male patients. The largest age group is adult at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female58.8%
Male26.0%
Unknown15.2%

Age group

< 20.0%
2–110.0%
12–170.6%
18–6455.3%
65+44.1%

What is diflunisal used for

Conditions and purposes for which patients were taking diflunisal when the adverse event was reported.

Abdominal PainAmyloidosisAntiinflammatory TherapyArthralgiaArthritisArthropathyAmyloidosisArthralgiaArthritisBack PainBlood Cholesterol AbnormalCancer PainCardiac AmyloidosisCardiac FailureChest Pain

Showing 15 of 56 indications

Diflunisal brand names and reporting trend

Diflunisal is sold under the brand name Dolobid.

Brand names

Dolobid665

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking diflunisal with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.