The most commonly reported side effects of difenoxin include macular degeneration, therapeutic product effect incomplete, and pain, based on 93 FDA adverse event reports from 2004 to 2025. 60.2% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for difenoxin.
These are voluntary reports and do not establish that difenoxin caused these reactions.
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Other drugs that appear in adverse event reports alongside difenoxin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
71.0% of difenoxin adverse event reports involve female patients and 17.2% involve male patients. The largest age group is elderly at 76%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking difenoxin when the adverse event was reported.
Difenoxin is sold under the brand name Motofen.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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