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Diethylstilbestrol Side Effects

The most commonly reported side effects of diethylstilbestrol include fatigue, myalgia, and nausea, based on 207 FDA adverse event reports from 2004 to 2025. 3.9% of reports found the drug to be ineffective.

Diethylstilbestrol side effects

Percentages show how often each reaction appears relative to total reports for diethylstilbestrol.

1
Fatigue5.3%11
2
Myalgia4.3%9
3
Nausea4.3%9
4
Drug Ineffective3.9%8
5
Pancreatitis3.9%8
6
Headache3.4%7
7
Prostate Cancer2.9%6
8
Myalgia2.9%6
9
Vomiting2.9%6
10
Neuralgia2.9%6
11
Nausea2.4%5
12
Prostatic Specific Antigen Increased2.4%5
13
Back Pain2.4%5
14
Embolism2.4%5
15
Death2.4%5

These are voluntary reports and do not establish that diethylstilbestrol caused these reactions.

Report severity

90.8%Serious188 reports
37.2%Hospitalizations77 reports
16.9%Fatal35 reports

Seriousness is determined by the reporter, not by OpenClaim.

Diethylstilbestrol drug interactions

Other drugs that appear in adverse event reports alongside diethylstilbestrol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole8.2%17
2
Dexamethasone7.7%16
3
Aspirin6.3%13
4
Valsartan5.8%12
5
Leuprolide4.8%10
6
Amlodipine4.8%10
7
Abiraterone-acetate4.8%10
8
Ceftriaxone-sodium4.3%9
9
Simvastatin4.3%9
10
Acetaminophen4.3%9
11
Atorvastatin-calcium4.3%9
12
Levothyroxine-sodium3.9%8
13
Metformin3.9%8
14
Hydrochlorothiazide3.9%8
15
Perindopril3.9%8

Taken alongside

1
Aspirin14.5%30
2
Acetaminophen9.7%20
3
Prednisone9.2%19
4
Lansoprazole8.2%17
5
Pravastatin-sodium8.2%17
6
Bicalutamide7.2%15
7
Sertraline-hydrochloride6.3%13
8
Omeprazole5.8%12
9
Prednisolone5.8%12
10
Ramipril5.8%12
11
Carbamazepine5.8%12
12
Hydrochlorothiazide5.3%11
13
Ibuprofen5.3%11
14
Tamsulosin-hydrochloride5.3%11
15
Ergocalciferol5.3%11

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports diethylstilbestrol side effects

36.2% of diethylstilbestrol adverse event reports involve female patients and 51.7% involve male patients. The largest age group is elderly at 49%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.2%
Male51.7%
Unknown12.1%

Age group

< 20.0%
2–111.3%
12–171.9%
18–6447.7%
65+49.0%

What is diethylstilbestrol used for

Conditions and purposes for which patients were taking diethylstilbestrol when the adverse event was reported.

Abortion SpontaneousAnxietyArthritisAdverse Drug ReactionBreast CancerCompleted SuicideConvulsion ProphylaxisContraceptionCystitis HaemorrhagicDiabetes MellitusDrug Use For Unknown IndicationEpilepsyGestational DiabetesGender DysphoriaHormone Level Abnormal

Showing 15 of 41 indications

Diethylstilbestrol brand names and reporting trend

Diethylstilbestrol is sold under brand names including Stilbetin, Stilphostrol.

Brand names

Stilbetin167
Stilphostrol32

Quarterly reports (20042025)

2005201020152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking diethylstilbestrol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.