OpenClaim

Dienestrol Side Effects

The most commonly reported side effects of dienestrol include endometriosis, drug intolerance, and hypertension, based on 56 FDA adverse event reports from 2005 to 2025. 82.1% of reports found the drug to be ineffective.

Dienestrol side effects

Percentages show how often each reaction appears relative to total reports for dienestrol.

1
Drug Ineffective82.1%46
2
Endometriosis80.4%45
3
Drug Intolerance80.4%45
4
Hypertension78.6%44
5
Asthma78.6%44
6
Chronic Kidney Disease78.6%44
7
Psoriasis78.6%44
8
Depression78.6%44
9
Arthritis78.6%44
10
Migraine76.8%43
11
Drug Specific Antibody53.6%30
12
Incorrect Route Of Product Administration39.3%22
13
Drug Specific Antibody Present33.9%19
14
Off Label Use7.1%4
15
Breast Cancer5.4%3

These are voluntary reports and do not establish that dienestrol caused these reactions.

Report severity

94.6%Serious53 reports
8.9%Hospitalizations5 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dienestrol drug interactions

Other drugs that appear in adverse event reports alongside dienestrol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Infliximab80.4%45
2
Methotrexate80.4%45
3
Amlodipine78.6%44
4
Acebutolol-hydrochloride78.6%44
5
Ergocalciferol78.6%44
6
Rosuvastatin78.6%44
7
Budesonide78.6%44
8
Adalimumab78.6%44
9
Telmisartan78.6%44
10
Venlafaxine78.6%44
11
Bupropion78.6%44
12
Dexlansoprazole78.6%44
13
Prednisone78.6%44
14
Albuterol76.8%43
15
Sumatriptan76.8%43

Taken alongside

1
Rosuvastatin5.4%3
2
Sumatriptan3.6%2
3
Telmisartan3.6%2
4
Venlafaxine3.6%2
5
Amlodipine3.6%2
6
Albuterol3.6%2
7
Bupropion3.6%2
8
Dexlansoprazole3.6%2
9
Acebutolol-hydrochloride3.6%2
10
Penicillin3.6%2
11
Estradiol1.8%1
12
Norgestimate1.8%1
13
Lithium1.8%1
14
Amoxicillin1.8%1
15
Bumetanide1.8%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dienestrol side effects

82.1% of dienestrol adverse event reports involve female patients and 5.4% involve male patients. The largest age group is adult at 94%. These figures reflect who reports side effects, not underlying risk.

Sex

Female82.1%
Male5.4%
Unknown12.5%

Age group

< 20.0%
2–110.0%
12–172.1%
18–6493.6%
65+4.3%

What is dienestrol used for

Conditions and purposes for which patients were taking dienestrol when the adverse event was reported.

Hormone Replacement TherapyProduct Used For Unknown IndicationProduct Used For Unknown IndicationUterine Haemorrhage

Dienestrol brand names and reporting trend

Dienestrol is sold under the brand name Estraguard.

Brand names

Estraguard58

Quarterly reports (20052025)

200520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dienestrol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.