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Didanosine Side Effects

The most commonly reported side effects of didanosine include foetal exposure during pregnancy, lipodystrophy acquired, and drug resistance, based on 6,253 FDA adverse event reports from 2004 to 2025.

Didanosine side effects

Percentages show how often each reaction appears relative to total reports for didanosine.

1
Foetal Exposure During Pregnancy7.7%480
2
Lipodystrophy Acquired3.6%224
3
Drug Resistance3.5%217
4
Drug Exposure During Pregnancy3.3%208
5
Pain3.3%208
6
Virologic Failure3.2%202
7
Emotional Distress3.2%200
8
Anxiety3.1%192
9
Eyelid Ptosis3.1%192
10
Mitochondrial Toxicity3.0%188
11
Viral Mutation Identified2.9%184
12
Lactic Acidosis2.9%181
13
Pyrexia2.8%174
14
Treatment Failure2.8%174
15
Anhedonia2.8%174

These are voluntary reports and do not establish that didanosine caused these reactions.

Report severity

95.2%Serious5,951 reports
33.6%Hospitalizations2,101 reports
10.8%Fatal677 reports

Seriousness is determined by the reporter, not by OpenClaim.

Didanosine drug interactions

Other drugs that appear in adverse event reports alongside didanosine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ritonavir36.2%2,266
2
Lamivudine34.9%2,182
3
Zidovudine32.6%2,037
4
Tenofovir29.5%1,844
5
Stavudine28.1%1,755
6
Nevirapine25.9%1,619
7
Efavirenz22.7%1,417
8
Lopinavir19.9%1,246
9
Abacavir18.1%1,129
10
Nelfinavir-mesylate13.3%829
11
Atazanavir-sulfate12.9%805
12
Emtricitabine12.5%782
13
Saquinavir11.0%685
14
Indinavir-sulfate10.2%637
15
Enfuvirtide6.7%420

Taken alongside

1
Ritonavir15.8%986
2
Lamivudine13.4%836
3
Tenofovir10.4%652
4
Lopinavir8.3%517
5
Zidovudine7.8%487
6
Sulfamethoxazole7.4%461
7
Abacavir7.3%454
8
Trimethoprim6.8%424
9
Stavudine6.2%385
10
Efavirenz6.0%375
11
Atazanavir-sulfate5.3%330
12
Emtricitabine5.2%326
13
Nevirapine4.1%256
14
Nelfinavir-mesylate4.0%253
15
Darunavir3.4%214

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports didanosine side effects

29.8% of didanosine adverse event reports involve female patients and 55.1% involve male patients. The largest age group is adult at 82%. These figures reflect who reports side effects, not underlying risk.

Sex

Female29.8%
Male55.1%
Unknown15.1%

Age group

< 28.0%
2–113.8%
12–172.5%
18–6481.7%
65+3.9%

What is didanosine used for

Conditions and purposes for which patients were taking didanosine when the adverse event was reported.

Acquired Immunodeficiency SyndromeAdverse EventAntiretroviral TherapyAntiviral ProphylaxisAntiviral TreatmentAsymptomatic Hiv InfectionAcquired Immunodeficiency SyndromeAntiretroviral TherapyCd4 Lymphocytes DecreasedChest DiscomfortChronic Hepatitis CCoronary DiseaseCoughChronic Hepatitis CDrug Exposure During Pregnancy

Showing 15 of 84 indications

Didanosine brand names and reporting trend

Didanosine is sold under the brand name Videx.

Brand names

Videx4,282

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking didanosine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.