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Dicloxacillin Side Effects

The most commonly reported side effects of dicloxacillin include acute kidney injury, drug reaction with eosinophilia and systemic symptoms, and pyrexia, based on 2,958 FDA adverse event reports from 2004 to 2025. 7.0% of reports found the drug to be ineffective.

Dicloxacillin side effects

Percentages show how often each reaction appears relative to total reports for dicloxacillin.

1
Acute Kidney Injury7.1%210
2
Drug Ineffective7.0%208
3
Drug Reaction With Eosinophilia And Systemic Symptoms5.4%160
4
Pyrexia4.2%124
5
Off Label Use3.4%102
6
Rash3.4%102
7
Drug Interaction2.9%87
8
Drug Hypersensitivity2.8%82
9
Nausea2.7%80
10
Diarrhoea2.6%78
11
Dyspnoea2.6%77
12
Pneumonia2.6%76
13
Renal Failure2.2%66
14
Fatigue2.2%64
15
Vomiting2.1%61

These are voluntary reports and do not establish that dicloxacillin caused these reactions.

Report severity

90.1%Serious2,665 reports
49.7%Hospitalizations1,469 reports
14.5%Fatal428 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dicloxacillin drug interactions

Other drugs that appear in adverse event reports alongside dicloxacillin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Vancomycin8.2%243
2
Clindamycin5.1%151
3
Ciprofloxacin4.9%146
4
Daptomycin4.6%135
5
Gentamicin-sulfate4.5%132
6
Acetaminophen4.2%123
7
Levofloxacin4.1%121
8
Ceftriaxone-sodium4.0%118
9
Metronidazole3.7%110
10
Meropenem3.3%98
11
Pantoprazole-sodium3.3%97
12
Methotrexate2.9%86
13
Rifampin2.9%86
14
Prednisone2.8%83
15
Amoxicillin2.7%81

Taken alongside

1
Acetaminophen16.7%495
2
Furosemide10.3%304
3
Vancomycin6.7%197
4
Pantoprazole-sodium6.3%185
5
Prednisone6.2%182
6
Aspirin6.1%181
7
Atorvastatin-calcium6.1%179
8
Levothyroxine-sodium5.7%170
9
Amlodipine5.6%167
10
Gabapentin5.5%164
11
Gentamicin-sulfate5.5%163
12
Albuterol5.3%158
13
Omeprazole5.3%158
14
Ondansetron5.1%150
15
Oxycodone5.0%148

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dicloxacillin side effects

40.9% of dicloxacillin adverse event reports involve female patients and 48.7% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.9%
Male48.7%
Unknown10.4%

Age group

< 24.3%
2–116.1%
12–174.2%
18–6453.3%
65+32.2%

What is dicloxacillin used for

Conditions and purposes for which patients were taking dicloxacillin when the adverse event was reported.

Abdominal InfectionAbscessAbscess LimbAcute Myeloid LeukaemiaAdverse EventAllergy TestAlternaria InfectionAnaemiaAnal AbscessAnimal BiteAnti-infective TherapyAntibiotic ProphylaxisAntibiotic TherapyAnticoagulant TherapyArthralgia

Showing 15 of 370 indications

Dicloxacillin brand names and reporting trend

Dicloxacillin is sold under the brand name Pathocil.

Brand names

Pathocil3,311

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dicloxacillin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.