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Dibucaine Side Effects

The most commonly reported side effects of dibucaine include malaise, nasopharyngitis, and dyspnoea, based on 194 FDA adverse event reports from 2004 to 2025.

Dibucaine side effects

Percentages show how often each reaction appears relative to total reports for dibucaine.

1
Malaise21.6%42
2
Nasopharyngitis19.6%38
3
Dyspnoea18.0%35
4
Dyspnoea Exertional17.5%34
5
Fall16.5%32
6
Pyrexia16.0%31
7
Chest Pain16.0%31
8
Asthma15.5%30
9
Productive Cough15.5%30
10
Injury14.9%29
11
Weight Decreased14.9%29
12
Angina Pectoris14.9%29
13
Cough14.9%29
14
Stress14.9%29
15
Nasal Congestion14.9%29

These are voluntary reports and do not establish that dibucaine caused these reactions.

Report severity

89.7%Serious174 reports
37.1%Hospitalizations72 reports
5.2%Fatal10 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dibucaine drug interactions

Other drugs that appear in adverse event reports alongside dibucaine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Atorvastatin-calcium20.1%39
2
Hydrocortisone17.5%34
3
Betamethasone17.0%33
4
Furosemide16.5%32
5
Mometasone-furoate16.0%31
6
Fluoxetine-hydrochloride16.0%31
7
Acetaminophen14.9%29
8
Metformin14.9%29
9
Ethinyl-estradiol14.4%28
10
Loperamide-hydrochloride14.4%28
11
Quinapril-hydrochloride14.4%28
12
Fluticasone14.4%28
13
Salmeterol-xinafoate14.4%28
14
Lactulose14.4%28
15
Nitrofurantoin14.4%28

Taken alongside

1
Hydrocortisone27.3%53
2
Acetaminophen26.3%51
3
Omeprazole19.6%38
4
Levothyroxine-sodium18.6%36
5
Atorvastatin-calcium16.0%31
6
Metformin14.9%29
7
Gabapentin12.4%24
8
Prednisone11.3%22
9
Lidocaine10.8%21
10
Pantoprazole-sodium10.8%21
11
Albuterol10.3%20
12
Furosemide9.8%19
13
Ranitidine9.3%18
14
Hydromorphone-hydrochloride8.8%17
15
Oxycodone8.8%17

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dibucaine side effects

57.2% of dibucaine adverse event reports involve female patients and 35.1% involve male patients. The largest age group is adult at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.2%
Male35.1%
Unknown7.7%

Age group

< 20.6%
2–110.0%
12–171.2%
18–6468.3%
65+29.8%

What is dibucaine used for

Conditions and purposes for which patients were taking dibucaine when the adverse event was reported.

Accidental ExposureAnalgesic TherapyBack PainBurning SensationDrug Exposure During PregnancyDrug Use For Unknown IndicationEar PainEpidural AnaesthesiaHaemorrhoidsHaemorrhoidsIll-defined DisorderLumbar RadiculopathyLocal AnaesthesiaPainProduct Used For Unknown Indication

Showing 15 of 24 indications

Dibucaine brand names and reporting trend

Dibucaine is sold under the brand name Heavy Solution Nupercaine.

Brand names

Heavy Solution Nupercaine232

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dibucaine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.