OpenClaim

Diazepam Side Effects

The most commonly reported side effects of diazepam include toxicity to various agents, drug abuse, and fatigue, based on 122,461 FDA adverse event reports from 2004 to 2025. 5.0% of reports found the drug to be ineffective.

#1 Reported: Toxicity To Various AgentsAll side effects ↓Top Co-Medication: Quetiapine-fumarateDrug interactions ↓73% of Reports Are AdultDemographics ↓

Diazepam side effects

Percentages show how often each reaction appears relative to total reports for diazepam.

1
Toxicity To Various Agents7.5%9,125
2
Drug Abuse5.7%7,031
3
Drug Ineffective5.0%6,111
4
Fatigue3.9%4,774
5
Nausea3.8%4,683
6
Off Label Use3.7%4,566
7
Somnolence3.4%4,132
8
Pain3.3%4,088
9
Headache3.2%3,900
10
Anxiety3.1%3,749
11
Drug Interaction2.9%3,502
12
Vomiting2.8%3,461
13
Overdose2.8%3,418
14
Death2.8%3,388
15
Fall2.8%3,373

These are voluntary reports and do not establish that diazepam caused these reactions.

Report severity

80.8%Serious99,001 reports
34.5%Hospitalizations42,211 reports
19.3%Fatal23,682 reports

Seriousness is determined by the reporter, not by OpenClaim.

Diazepam drug interactions

Other drugs that appear in adverse event reports alongside diazepam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate5.3%6,508
2
Acetaminophen5.1%6,303
3
Oxycodone4.8%5,870
4
Pregabalin4.3%5,289
5
Methadone-hydrochloride3.8%4,665
6
Olanzapine3.4%4,180
7
Alprazolam3.4%4,146
8
Tramadol-hydrochloride3.3%4,032
9
Fentanyl3.1%3,737
10
Gabapentin2.6%3,242
11
Cocaine-hydrochloride2.6%3,180
12
Clonazepam2.5%3,015
13
Apomorphine-hydrochloride2.5%3,009
14
Lorazepam2.4%2,954
15
Risperidone2.4%2,883

Taken alongside

1
Acetaminophen15.3%18,793
2
Gabapentin8.3%10,104
3
Omeprazole8.0%9,844
4
Aspirin7.8%9,588
5
Albuterol7.5%9,184
6
Oxycodone7.5%9,180
7
Ergocalciferol7.4%9,040
8
Levothyroxine-sodium7.3%8,895
9
Hydrocodone6.2%7,622
10
Ibuprofen6.0%7,361
11
Furosemide5.6%6,805
12
Atorvastatin-calcium5.4%6,565
13
Amlodipine4.7%5,773
14
Fluticasone4.6%5,659
15
Ondansetron4.6%5,632

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports diazepam side effects

52.8% of diazepam adverse event reports involve female patients and 38.7% involve male patients. The largest age group is adult at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.8%
Male38.7%
Unknown8.5%

Age group

< 21.4%
2–112.4%
12–172.2%
18–6473.5%
65+20.5%

What is diazepam used for

Conditions and purposes for which patients were taking diazepam when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal OperationAbdominal PainAbdominal Pain UpperAbdominal RigidityAbnormal BehaviourAbnormal DreamsAbstains From AlcoholAccidentAccident At WorkAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAccidental Overdose

Showing 15 of 1,556 indications

Diazepam brand names and reporting trend

Diazepam is sold under the brand name Q-pam.

Brand names

Q-pam99,298

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking diazepam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

Check my medications