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Dextrothyroxine Side Effects

The most commonly reported side effects of dextrothyroxine include fatigue, dyspnoea, and nausea, based on 8,676 FDA adverse event reports from 2004 to 2025. 3.8% of reports found the drug to be ineffective.

Dextrothyroxine side effects

Percentages show how often each reaction appears relative to total reports for dextrothyroxine.

1
Fatigue5.5%475
2
Dyspnoea5.0%435
3
Nausea5.0%433
4
Malaise4.9%426
5
Diarrhoea4.7%412
6
Headache4.7%407
7
Arthralgia4.0%350
8
Drug Ineffective3.8%327
9
Off Label Use3.6%316
10
Dizziness3.6%312
11
Fall3.1%273
12
Pain3.1%272
13
Asthenia2.9%251
14
Vomiting2.9%249
15
Pain In Extremity2.7%237

These are voluntary reports and do not establish that dextrothyroxine caused these reactions.

Report severity

89.3%Serious7,746 reports
39.2%Hospitalizations3,404 reports
9.0%Fatal785 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dextrothyroxine drug interactions

Other drugs that appear in adverse event reports alongside dextrothyroxine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Somatropin2.7%233
2
Adalimumab2.7%230
3
Metformin2.0%175
4
Atorvastatin-calcium2.0%174
5
Clozapine1.9%167
6
Quetiapine-fumarate1.7%144
7
Omeprazole1.5%134
8
Etanercept1.5%131
9
Infliximab1.5%130
10
Dexamethasone1.5%130
11
Olanzapine1.5%126
12
Aspirin1.4%121
13
Prednisone1.4%121
14
Methotrexate1.3%117
15
Nivolumab1.3%116

Taken alongside

1
Aspirin10.6%917
2
Acetaminophen8.6%744
3
Omeprazole8.4%727
4
Atorvastatin-calcium8.1%702
5
Furosemide7.1%615
6
Simvastatin6.9%601
7
Metformin6.8%590
8
Amlodipine6.5%567
9
Ergocalciferol6.2%539
10
Folic-acid5.9%514
11
Hydrocortisone4.4%383
12
Insulin4.3%371
13
Pantoprazole-sodium4.3%370
14
Hydrochlorothiazide4.2%368
15
Albuterol4.2%363

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dextrothyroxine side effects

70.2% of dextrothyroxine adverse event reports involve female patients and 23.4% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female70.2%
Male23.4%
Unknown6.4%

Age group

< 21.8%
2–111.2%
12–171.0%
18–6449.7%
65+46.3%

What is dextrothyroxine used for

Conditions and purposes for which patients were taking dextrothyroxine when the adverse event was reported.

AcromegalyAdrenal InsufficiencyAnkylosing SpondylitisAntiplatelet TherapyArthralgiaAsthmaAutoimmune HepatitisAutoimmune HypothyroidismAutoimmune Thyroid DisorderAutoimmune ThyroiditisAdverse EventArthralgiaAspartate Aminotransferase IncreasedAtrial FibrillationAutoimmune Hepatitis

Showing 15 of 172 indications

Dextrothyroxine brand names and reporting trend

Dextrothyroxine is sold under the brand name Choloxin.

Brand names

Choloxin9,032

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dextrothyroxine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.